Biology:Emperipolesis
Emperipolesis is the presence of an intact cell within the cytoplasm of another cell.[1] It is derived from Greek (en is inside, peripoleomai is go round).[2] Emperipolesis is an uncommon biological process, and can be physiological or pathological.[3]
It is related to peripolesis, which is the attachment of one cell to another.[4]
Emperipolesis is unlike phagocytosis, in which the engulfed cell is killed by the lysosomal enzymes of the macrophage. Instead, the engulfed cell remains viable within the other, and can exit at any time without causing structural or functional abnormalities in either cell.[3]
Classification
Emperipolesis has been classified into two categories:[3]
- Engulfment of hemapoietic cells by megakaryocytes such as in hematolymphoid disorders (Hodgkin's disease, leukemia, acute and chronic myeloid leukemia, non-Hodgkin's lymphoma, myeloproliferative disorders, myelodysplastic syndrome)
- Engulfment of inflammatory cells by histiocytes, which is a hallmark of Rosai-Dorfman disease[5]
Other associations
It is seen in various conditions including:
- Autoimmune hepatitis[6]
- Leukocyte migration from the blood stream to tissues through endothelial cells, in a process also known as transcellular migration and is akin to diapedesis (paracellular migration).
Additional images
Emperipolesis: a band neutrophil inside a megakaryocyte (Wright-Giemsa, 100x, oil).
Emperipolesis in Rosai-Dorfman disease highlighted by S-100 staining.
Emperipolesis: Megakaryocyte containing a segmented neutrophil, stained with a May-Grünwald Giemsa stain.
See also
- Hemophagocytic syndrome
- Phagocytosis
- Symbiogenesis
References
- ↑ Emperipolesis. dictionary.com. URL: http://dictionary.reference.com/browse/emperipolesis. Accessed on: 11 August 2010.
- ↑ Emperipolesis. Stedman's Medical Dictionary. 27th Ed.
- ↑ 3.0 3.1 3.2 Rastogi, Varun; Sharma, Rachna; Misra, Satya; Yadav, Lalita; Sharma, Vandana (2014). "Emperipolesis – A Review". Journal of Clinical and Diagnostic Research 8 (12): ZM01–ZM02. doi:10.7860/jcdr/2014/10361.5299. PMID 25654060.
- ↑ "Lymphocyte macrophage interactions: peripolesis of human alveolar macrophages". Eur. Respir. J. 5 (1): 59–66. January 1992. PMID 1577151.
- ↑ "Primary Rosai-Dorfman Disease of Bone: A Clinicopathologic Study of 15 Cases". Am J Surg Pathol 34 (9): 1324–1333. July 2010. doi:10.1097/PAS.0b013e3181ea50b2. PMID 20679880.
- ↑ "Pathology of autoimmune hepatitis". Pathologica 113 (3): 185-193. 2021. doi:10.32074/1591-951X-241. PMID 34294936.
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