Biology:O-acetylhomoserine aminocarboxypropyltransferase
O-acetylhomoserine aminocarboxypropyltransferase | |||||||||
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Identifiers | |||||||||
EC number | 2.5.1.49 | ||||||||
CAS number | 37290-90-7 | ||||||||
Databases | |||||||||
IntEnz | IntEnz view | ||||||||
BRENDA | BRENDA entry | ||||||||
ExPASy | NiceZyme view | ||||||||
KEGG | KEGG entry | ||||||||
MetaCyc | metabolic pathway | ||||||||
PRIAM | profile | ||||||||
PDB structures | RCSB PDB PDBe PDBsum | ||||||||
Gene Ontology | AmiGO / QuickGO | ||||||||
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In enzymology, an O-acetylhomoserine aminocarboxypropyltransferase (EC 2.5.1.49) is an enzyme that catalyzes the chemical reaction
- O-acetyl-L-homoserine + methanethiol [math]\displaystyle{ \rightleftharpoons }[/math] L-methionine + acetate
Thus, the two substrates of this enzyme are O-acetyl-L-homoserine and methanethiol, whereas its two products are L-methyionine and acetate.
This enzyme belongs to the family of transferases, specifically those transferring aryl or alkyl groups other than methyl groups. The systematic name of this enzyme class is O-acetyl-L-homoserine:methanethiol 3-amino-3-carboxypropyltransferase. Other names in common use include O-acetyl-L-homoserine acetate-lyase (adding methanethiol), O-acetyl-L-homoserine sulfhydrolase, O-acetylhomoserine (thiol)-lyase, O-acetylhomoserine sulfhydrolase, and methionine synthase. This enzyme participates in methionine metabolism and cysteine metabolism.
References
- Kerr D (1971). "O-Acetylhomoserine sulfhydrylase (Neurospora)". Methods Enzymol. 17B: 446–450. doi:10.1016/0076-6879(71)17079-6.
- "Utilization of S-methylcysteine and methylmercaptan by methionineless mutants of Neurospora and the pathway of their conversion to methionine. II. Enzyme studies". Biochim. Biophys. Acta 184 (1): 130–8. 1969. doi:10.1016/0304-4165(69)90107-x. PMID 5791104.
- "O-Acetylserine and O-acetylhomoserine sulfhydrylase of yeast Further purification and characterization as a pyridoxal enzyme". J. Biochem. (Tokyo) 80 (4): 777–85. October 1976. doi:10.1093/oxfordjournals.jbchem.a131338. PMID 795806.
- Yamagata S (October 1976). "O-Acetylserine and O-acetylhomoserine sulfhydrylase of yeast. Subunit structure". J. Biochem. (Tokyo) 80 (4): 787–97. PMID 795807.
- "Evidence for the identity of O-acetylserine sulfhydrylase with O-acetylhomoserine sulfhydrylase in yeast". J. Biochem. (Tokyo) 75 (6): 1221–9. June 1974. PMID 4609980.
- Yamagata S (1989). "Roles of O-acetyl-L-homoserine sulfhydrylases in micro-organisms". Biochimie 71 (11–12): 1125–43. doi:10.1016/0300-9084(89)90016-3. PMID 2517474.
- "Cloning and overexpression of the oah1 gene encoding O-acetyl-L-homoserine sulfhydrylase of Thermus thermophilus HB8 and characterization of the gene product". Biochim. Biophys. Acta 1549 (1): 61–72. 2001. doi:10.1016/S0167-4838(01)00245-X. PMID 11566369.
![]() | Original source: https://en.wikipedia.org/wiki/O-acetylhomoserine aminocarboxypropyltransferase.
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