Biology:Spermine synthase
| Spermine synthase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 2.5.1.22 | ||||||||
| CAS number | 74812-43-4 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
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Spermine synthase (EC 2.5.1.22, spermidine aminopropyltransferase, spermine synthetase) is an enzyme that converts spermidine into spermine.[1][2] This enzyme catalyses the following chemical reaction
- S-adenosylmethioninamine + spermidine [math]\displaystyle{ \rightleftharpoons }[/math] S-methyl-5'-thioadenosine + spermine
Spermine synthase is an enzyme involved in polyamine biosynthesis. It is present in all eukaryotes and plays a role in a variety of biological functions in plants[3] Its structure consists of two identical monomers of 41 kDa with three domains each, creating a homodimer formed via dimerization. The interactions between one of the three domains, the N-terminals of the monomers, is responsible for dimerization as that is where the active site is located; the central terminal consisting of four β- strands structurally forming a lid for the third domain, the C-terminal domain.[4]
References
- ↑ "Studies of inhibition of rat spermidine synthase and spermine synthase". The Biochemical Journal 187 (2): 419–28. May 1980. doi:10.1042/bj1870419. PMID 7396856.
- ↑ "Polyamine synthesis in mammalian tissues. Isolation and characterization of spermine synthase from bovine brain". European Journal of Biochemistry 101 (2): 619–26. November 1979. doi:10.1111/j.1432-1033.1979.tb19756.x. PMID 520313.
- ↑ "Characterization of spermidine synthase and spermine synthase--The polyamine-synthetic enzymes that induce early flowering in Gentiana triflora". Biochemical and Biophysical Research Communications 463 (4): 781–6. August 2015. doi:10.1016/j.bbrc.2015.06.013. PMID 26056006.
- ↑ "Spermine synthase". Cellular and Molecular Life Sciences 67 (1): 113–21. January 2010. doi:10.1007/s00018-009-0165-5. PMID 19859664.
External links
- Spermine+synthase at the US National Library of Medicine Medical Subject Headings (MeSH)
- EC 2.5.1.22
- SMS
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