Biology:Enoyl-(acyl-carrier-protein) reductase (NADPH, A-specific)
| enoyl-[acyl-carrier-protein] reductase (NADPH, A-specific) | |||||||||
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| Identifiers | |||||||||
| EC number | 1.3.1.39 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
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In enzymology, an enoyl-[acyl-carrier-protein] reductase (NADPH, A-specific) (EC 1.3.1.39) is an enzyme that catalyzes the chemical reaction
- acyl-[acyl-carrier-protein] + NADP+ [math]\displaystyle{ \rightleftharpoons }[/math] trans-2,3-dehydroacyl-[acyl-carrier-protein] + NADPH + H+
Thus, the two substrates of this enzyme are acyl-[acyl-carrier-protein] and NADP+, whereas its 3 products are trans-2,3-dehydroacyl-[acyl-carrier-protein], NADPH, and H+.
This enzyme belongs to the family of oxidoreductases, to be specific, those acting on the CH-CH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is acyl-[acyl-carrier-protein]:NADP+ oxidoreductase (A-specific). Other names in common use include acyl-ACP dehydrogenase, enoyl-[acyl carrier protein] (reduced nicotinamide adenine, dinucleotide phosphate) reductase, NADPH 2-enoyl Co A reductase, enoyl-ACp reductase, and enoyl-[acyl-carrier-protein] reductase (NADPH2, A-specific).
References
- "Stereospecificity of the transfer of hydrogen from reduced nicotinamide adenine dinucleotide phosphate to the acyl chain in the dehydrogenase-catalyzed reactions of fatty acid synthesis". J. Biol. Chem. 245 (23): 6312–6. 1970. PMID 4394955.
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