Biology:SRD5A3
From HandWiki
Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
Steroid 5-alpha-reductase 3, also known as 3-oxo-5-alpha-steroid 4-dehydrogenase 3, is an enzyme that in humans is encoded by the SRD5A3 gene.[1][2] It is one of three forms of 5α-reductase. Unlike SRD5A1 and SRD5A2, SRD5A3 has no apparent form in androgen processing or signaling. Instead, SRD5A3 reduces polyprenol to dolichol, which is necessary for N-linked glycosylation of proteins and some lipids.[3]
See also
- SRD5A3-CDG
- Congenital disorder of glycosylation
- Kahrizi syndrome, a syndrome caused by a mutation in this gene
References
- ↑ "Entrez Gene: steroid 5 alpha-reductase 3". https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=79644.
- ↑ "Novel 5 alpha-steroid reductase (SRD5A3, type-3) is overexpressed in hormone-refractory prostate cancer". Cancer Science 99 (1): 81–86. January 2008. doi:10.1111/j.1349-7006.2007.00656.x. PMID 17986282.
- ↑ "SRD5A3 is required for converting polyprenol to dolichol and is mutated in a congenital glycosylation disorder". Cell 142 (2): 203–217. July 2010. doi:10.1016/j.cell.2010.06.001. PMID 20637498.
Further reading
- "Overview of steroidogenic enzymes in the pathway from cholesterol to active steroid hormones.". Endocrine Reviews 25 (6): 947–970. Dec 2004. doi:10.1210/er.2003-0030. PMID 15583024.
- "SRD5A3 is required for converting polyprenol to dolichol and is mutated in a congenital glycosylation disorder.". Cell 142 (2): 203–217. Jul 2010. doi:10.1016/j.cell.2010.06.001. PMID 20637498.
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