Biology:TRNA (pseudouridine54-N1)-methyltransferase
From HandWiki
| TRNA (pseudouridine54-N1)-methyltransferase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 2.1.1.257 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
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TRNA (pseudouridine54-N1)-methyltransferase (EC 2.1.1.257, TrmY, m1Psi methyltransferase) is an enzyme with systematic name S-adenosyl-L-methionine:tRNA (pseudouridine54-N1)-methyltransferase.[1][2][3] This enzyme catalyses the following chemical reaction
- S-adenosyl-L-methionine + pseudouridine54 in tRNA [math]\displaystyle{ \rightleftharpoons }[/math] S-adenosyl-L-homocysteine + N1-methylpseudouridine54 in tRNA
This archaeal enzyme is specific for the 54 position.
References
- ↑ "Crystal structure of Mj1640/DUF358 protein reveals a putative SPOUT-class RNA methyltransferase". Journal of Molecular Cell Biology 2 (6): 366–74. December 2010. doi:10.1093/jmcb/mjq034. PMID 21098051.
- ↑ "Identification of the enzyme responsible for N1-methylation of pseudouridine 54 in archaeal tRNAs". RNA 18 (3): 412–20. March 2012. doi:10.1261/rna.028498.111. PMID 22274954.
- ↑ "The archaeal COG1901/DUF358 SPOUT-methyltransferase members, together with pseudouridine synthase Pus10, catalyze the formation of 1-methylpseudouridine at position 54 of tRNA". RNA 18 (3): 421–33. March 2012. doi:10.1261/rna.030841.111. PMID 22274953.
External links
- TRNA+(pseudouridine54-N1)-methyltransferase at the US National Library of Medicine Medical Subject Headings (MeSH)
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