Chemistry:Thiophene-2-carboxaldehyde
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| Names | |
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| Preferred IUPAC name
Thiophene-2-carbaldehyde | |
| Other names
2-formylthiophene, thiophene-2-aldehyde, T2A, 2-thiophenecarboxaldehyde
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| Identifiers | |
3D model (JSmol)
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| Properties | |
| C5H4OS | |
| Molar mass | 112.15 g·mol−1 |
| Appearance | colorless liquid |
| Density | 1.2 g/mL |
| Boiling point | 198 °C (388 °F; 471 K) |
| Hazards | |
| GHS pictograms | 
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| GHS Signal word | Warning |
| H302, H315, H317, H319, H335 | |
| P261, P264, P270, P271, P272, P280, P301+312, P302+352, P304+340, P305+351+338, P312, P321, P330, P332+313, P333+313, P337+313, P362, P363, P403+233, P405, P501 | |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). | |
| Infobox references | |
Thiophene-2-carboxaldehyde is an organosulfur compound with the formula C4H3SCHO. It is one of two isomeric thiophenecarboxaldehydes. It is a colorless liquid that often appears amber after storage. It is versatile precursor to many drugs including eprosartan, Azosemide, and Teniposide.
Preparation
It can be prepared from thiophene by the Vilsmeier reaction.[1] Alternatively, it is prepared from chloromethylation of thiophene.[2]
References
- ↑ Jonathan Swanston (2006). "Ullmann's Encyclopedia of Industrial Chemistry". Ullmann's Encyclopedia of Industrial Chemistry. Weinheim: Wiley-VCH. doi:10.1002/14356007.a26_793.pub2.
- ↑ Kenneth B. Wiberg. "2-Thiophenealdehyde". Org. Synth. 3: 811. doi:10.15227/orgsyn.000.0005.
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