Biology:Coenzyme F420-1:gamma-L-glutamate ligase

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Short description: Class of enzymes
Coenzyme F420-1:γ-L-glutamate ligase
Identifiers
EC number6.3.2.34
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum

Coenzyme F420-1:γ-L-glutamate ligase (EC 6.3.2.34, F420:gamma-glutamyl ligase, CofE-AF, MJ0768, CofE) is an enzyme with systematic name L-glutamate:coenzyme F420-1 ligase (GDP-forming).[1][2] This enzyme catalyses the following chemical reaction

GTP + coenzyme F420-1 + L-glutamate [math]\displaystyle{ \rightleftharpoons }[/math] GDP + phosphate + coenzyme γ-F420-2

In some instances, this enzyme is fused with a coenzyme F420-0:L-glutamate ligase domain, so that the coenzyme F420-1 produced by the latter is quickly ligated to coenzyme F420-2. This enzyme is also able to serially add additional γ-glutamyl groups to F420-2, producing F420-3 and so on.[3]

References

External links