Biology:Geissoschizine dehydrogenase
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Short description: Class of enzymes
| geissoschizine dehydrogenase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 1.3.1.36 | ||||||||
| CAS number | 84399-94-0 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
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In enzymology, a geissoschizine dehydrogenase (EC 1.3.1.36) is an enzyme that catalyzes the chemical reaction
- geissoschizine + NADP+ [math]\displaystyle{ \rightleftharpoons }[/math] 4,21-didehydrogeissoschizine + NADPH
Thus, the two substrates of this enzyme are geissoschizine and NADP+, whereas its two products are 4,21-didehydrogeissoschizine and NADPH.
This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-CH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is geissoschizine:NADP+ 4,21-oxidoreductase. This enzyme participates in indole and ipecac alkaloid biosynthesis.
References
- "Partial-purification and characterization of geissoschizine dehydrogenase from suspension-cultures of Catharanthus roseus". Phytochemistry 21: 1585–1588. 1982. doi:10.1016/s0031-9422(82)85022-x.
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