Biology:Gluconate dehydratase
From HandWiki
Short description: Class of enzymes
| gluconate dehydratase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 4.2.1.39 | ||||||||
| CAS number | 37290-75-8 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
The enzyme gluconate dehydratase (EC 4.2.1.39) catalyzes the chemical reaction
- D-gluconate [math]\displaystyle{ \rightleftharpoons }[/math] 2-dehydro-3-deoxy-D-gluconate + H2O
This enzyme belongs to the family of lyases, specifically the hydro-lyases, which cleave carbon-oxygen bonds. The systematic name of this enzyme class is D-gluconate hydro-lyase (2-dehydro-3-deoxy-D-gluconate-forming). Other names in common use include D-gluconate dehydratase, and D-gluconate hydro-lyase. This enzyme participates in the pentose phosphate pathway.
Structural studies
As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code 1QJ4.
References
- "The occurrence of a modified Entner-doudoroff pathway in Clostridium aceticum". Arch. Mikrobiol. 69 (2): 160–70. 1969. doi:10.1007/BF00409760. PMID 5383859.
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