Biology:Glycochenodeoxycholate sulfotransferase
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Short description: Class of enzymes
| Glycochenodeoxycholate sulfotransferase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 2.8.2.34 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
In enzymology, a glycochenodeoxycholate sulfotransferase (EC 2.8.2.34) is an enzyme that catalyzes the chemical reaction
- 3'-phosphoadenylyl sulfate + glycochenodeoxycholate [math]\displaystyle{ \rightleftharpoons }[/math] adenosine 3',5'-bisphosphate + glycochenodeoxycholate 7-sulfate
Thus, the two substrates of this enzyme are 3'-phosphoadenylyl sulfate and glycochenodeoxycholate, whereas its two products are adenosine 3',5'-bisphosphate and glycochenodeoxycholate 7-sulfate.
Nomenclature
This enzyme belongs to the family of transferases, specifically the sulfotransferases, which transfer sulfur-containing groups. The systematic name of this enzyme class is 3'-phosphoadenylyl-sulfate:glycochenodeoxycholate 7-sulfotransferase. Other names in common use include bile acid:3'-phosphoadenosine-5'-phosphosulfate sulfotransferase, bile acid:PAPS:sulfotransferase, and BAST.
References
Further reading
- "Enzymatic sulfation of glycochenodeoxycholic acid by tissue fractions from adult hamsters". Journal of Lipid Research 20 (8): 952–9. November 1979. PMID 533830.
- "The enzymes, regulation, and genetics of bile acid synthesis". Annual Review of Biochemistry 72: 137–74. 2003. doi:10.1146/annurev.biochem.72.121801.161712. PMID 12543708.
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