Biology:Malyl-CoA lyase

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malyl-CoA lyase
Identifiers
EC number4.1.3.24
CAS number37290-67-8
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO

The enzyme malyl-CoA lyase (EC 4.1.3.24) catalyzes the chemical reaction

(3S)-3-carboxy-3-hydroxypropanoyl-CoA [math]\displaystyle{ \rightleftharpoons }[/math] acetyl-CoA + glyoxylate

This enzyme belongs to the family of lyases, specifically the oxo-acid-lyases, which cleave carbon-carbon bonds. The systematic name of this enzyme class is (3S)-3-carboxy-3-hydroxypropanoyl-CoA glyoxylate-lyase (acetyl-CoA-forming). Other names in common use include malyl-coenzyme A lyase, and (3S)-3-carboxy-3-hydroxypropanoyl-CoA glyoxylate-lyase. This enzyme participates in glyoxylate and dicarboxylate metabolism.

References

  • "Enzymic cleavage of malyl-Coenzyme A into acetyl-Coenzyme A and glyoxylic acid". Biochim. Biophys. Acta 96: 148–153. 1965. doi:10.1016/0005-2787(65)90618-0.