Biology:N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase
From HandWiki
| N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 2.8.2.33 | ||||||||
| CAS number | 242469-38-1 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
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N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase (EC 2.8.2.33, GalNAc4S-6ST, CHST15 (gene)) is an enzyme with systematic name 3'-phosphoadenylyl-sulfate:(dermatan)-4-O-sulfo-N-acetyl-D-galactosamine 6-O-sulfotransferase.[1][2] This enzyme catalyses the following chemical reaction
- (1) 3-phospho-5-adenylyl sulfate + [dermatan]-4-O-sulfo-N-acetyl-D-galactosamine [math]\displaystyle{ \rightleftharpoons }[/math] adenosine 3',5'-bisphosphate + [dermatan]-4,6-di-O-sulfo-N-acetyl-D-galactosamine
- (2) 3-phospho-5-adenylyl sulfate + [chondroitin]-4-O-sulfo-N-acetyl-D-galactosamine [math]\displaystyle{ \rightleftharpoons }[/math] adenosine 3',5'-bisphosphate + [chondroitin]-4,6-di-O-sulfo-N-acetyl-D-galactosamine
The enzyme is activated by divalent cations and reduced glutathione.
Human proteins containing this domain
- CHST15
References
- ↑ "Purification and characterization of N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase from the squid cartilage". The Journal of Biological Chemistry 275 (44): 34728–36. November 2000. doi:10.1074/jbc.M909633199. PMID 10871629.
- ↑ "Human N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase cDNA is related to human B cell recombination activating gene-associated gene". The Journal of Biological Chemistry 276 (47): 43894–900. November 2001. doi:10.1074/jbc.M104922200. PMID 11572857.
External links
- N-acetylgalactosamine+4-sulfate+6-O-sulfotransferase at the US National Library of Medicine Medical Subject Headings (MeSH)
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