Biology:TRNA-dihydrouridine20 synthase (NAD(P)+)
From HandWiki
Short description: Class of enzymes
| TRNA-dihydrouridine20 synthase (NAD(P)+) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 1.3.1.91 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
TRNA-dihydrouridine20 synthase (NAD(P)+) (EC 1.3.1.91, Dus2p, tRNA-dihydrouridine synthase 2) is an enzyme with systematic name tRNA-5,6-dihydrouracil20:NAD(P)+ oxidoreductase.[1][2][3][4] This enzyme catalyses the following chemical reaction
- 5,6-dihydrouracil20 in tRNA + NAD(P)+ [math]\displaystyle{ \rightleftharpoons }[/math] uracil20 in tRNA + NAD(P)H + H+
This enzyme specifically modifies uracil20 in tRNA.
References
- ↑ "The specificities of four yeast dihydrouridine synthases for cytoplasmic tRNAs". The Journal of Biological Chemistry 279 (17): 17850–60. April 2004. doi:10.1074/jbc.M401221200. PMID 14970222.
- ↑ "A conserved family of Saccharomyces cerevisiae synthases effects dihydrouridine modification of tRNA". RNA 8 (3): 370–81. March 2002. doi:10.1017/S1355838202029825. PMID 12003496.
- ↑ "Mechanism of dihydrouridine synthase 2 from yeast and the importance of modifications for efficient tRNA reduction". The Journal of Biological Chemistry 284 (16): 10324–33. April 2009. doi:10.1074/jbc.M806137200. PMID 19139092.
- ↑ "A novel human tRNA-dihydrouridine synthase involved in pulmonary carcinogenesis". Cancer Research 65 (13): 5638–46. July 2005. doi:10.1158/0008-5472.CAN-05-0600. PMID 15994936.
External links
- TRNA-dihydrouridine20+synthase+(NAD(P)+) at the US National Library of Medicine Medical Subject Headings (MeSH)
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