Biography:Catherine Blish

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Short description: Translational immunologist


Catherine Blish
CitizenshipUnited States
EducationBS, University of California, Davis, Biochemistry (1993)

PhD, University of Washington, Immunology (1999) MD, University of Washington (2001) Residency: University of Washington Medical Center (2003)

American Board of Internal Medicine, Infectious Diseases (2006)
Known forInnate immune system, HIV/AIDS, NK cells
AwardsICAAC Young Investigator Award, American Society for Microbiology (2010)

NIH Director's New Innovator Award, National Institutes of Health (2013)

Elected Member, American Society for Clinical Investigation (2016) Fellow, Infectious Diseases Society of America (2017)

Chan Zuckerberg Investigator (2017)
Scientific career
FieldsImmunology
InstitutionsStanford University
Websitehttps://med.stanford.edu/blishlab.html

Catherine Blish is a translational immunologist and professor at Stanford University. Her lab works on clinical immunology and focuses primarily on the role of the innate immune system in fighting infectious diseases like HIV, dengue fever, and influenza. Her immune cell biology work characterizes the biology and action of Natural Killer (NK) cells and macrophages.[1]

For her previous and ongoing work fighting HIV/AIDS, Blish was awarded the 2018 Avant-Garde Award from the National Institute on Drug Abuse.[2]

Contributions to immunology

Natural Killer cell immune memory

A key concept in the adaptive immune system, and the foundational science behind vaccines, is that some elements of the immune system recognizes antigens it has seen before in a process called as immunological memory.[3] Dr. Blish and colleagues have identified a potential mechanism through which NK cells may also display immune memory.[4] This is unusual and shifts the accepted paradigm because NK cells are typically considered part of the innate immune system, not the adaptive immune system. Dr. Blish and colleagues demonstrate antigen-specific recognition, and memory of viruses and viral antigens by NK cells in mice and primates.

Key papers

The papers authored or co-authored by Dr. Blish that have been cited ~100 or more times are:

  • "Genetic and environmental determinants of human NK cell diversity revealed by mass cytometry," Science Translational Medicine.[5]
  • "Intrinsic retroviral reactivation in human preimplantation embryos and pluripotent cells," Nature.[6]
  • "Breadth of neutralizing antibody response to human immunodeficiency virus type 1 is affected by factors early in infection but does not influence disease progression," Journal of Virology.[7]
  • "Human immunodeficiency virus type 1 superinfection occurs despite relatively robust neutralizing antibody responses," Journal of Virology.[8]
  • "Human NK cell repertoire diversity reflects immune experience and correlates with viral susceptibility," Science Translational Medicine.[9]
  • "Enhancing exposure of HIV-1 neutralization epitopes through mutations in gp41," PLOS Medicine.[10]
  • "HIV-1 subtype A envelope variants from early in infection have variable sensitivity to neutralization and to inhibitors of viral entry," AIDS.[11]

COVID-19

In 2020, Dr. Blish's lab pivoted to work on SARS-CoV-2 due to the COVID-19 pandemic.[12][13] With colleagues, the Blish lab is scrutinizing ways chloroquine interferes with the viral life cycle.[14]

Honors

  • Chan Zuckerberg Investigator (2017),[15][16] Chan Zuckerberg Initiative
  • National Institute of Health Director's New Innovator Award (2013)[17]

References list

  1. ↑ "Catherine Blish: Immunology is on the trail of a killer" (in en). 2020-04-27. https://engineering.stanford.edu/magazine/article/catherine-blish-immunology-trail-killer. 
  2. ↑ "NIDA's 2018 Avant-Garde awards highlight immune response and killer cells" (in EN). 2018-03-13. https://www.nih.gov/news-events/news-releases/nidas-2018-avant-garde-awards-highlight-immune-response-killer-cells. 
  3. ↑ Immunobiology 5 : the immune system in health and disease. Janeway, Charles. (5th ed.). New York: Garland Pub. 2001. ISBN 978-0-8153-3642-6. OCLC 45708106. 
  4. ↑ "Redefining Memory: Building the Case for Adaptive NK Cells". Journal of Virology 91 (20): e00169–17, e00169–17. October 2017. doi:10.1128/JVI.00169-17. PMID 28794018. 
  5. ↑ "Genetic and environmental determinants of human NK cell diversity revealed by mass cytometry". Science Translational Medicine 5 (208): 208ra145. October 2013. doi:10.1126/scitranslmed.3006702. PMID 24154599. 
  6. ↑ "Intrinsic retroviral reactivation in human preimplantation embryos and pluripotent cells". Nature 522 (7555): 221–5. June 2015. doi:10.1038/nature14308. PMID 25896322. Bibcode: 2015Natur.522..221G. 
  7. ↑ "Breadth of neutralizing antibody response to human immunodeficiency virus type 1 is affected by factors early in infection but does not influence disease progression". Journal of Virology 83 (19): 10269–74. October 2009. doi:10.1128/JVI.01149-09. PMID 19640996. 
  8. ↑ "Human immunodeficiency virus type 1 superinfection occurs despite relatively robust neutralizing antibody responses". Journal of Virology 82 (24): 12094–103. December 2008. doi:10.1128/JVI.01730-08. PMID 18842728. 
  9. ↑ "Human NK cell repertoire diversity reflects immune experience and correlates with viral susceptibility". Science Translational Medicine 7 (297): 297ra115. July 2015. doi:10.1126/scitranslmed.aac5722. PMID 26203083. 
  10. ↑ "Enhancing exposure of HIV-1 neutralization epitopes through mutations in gp41". PLOS Medicine 5 (1): e9. January 2008. doi:10.1371/journal.pmed.0050009. PMID 18177204. 
  11. ↑ "HIV-1 subtype A envelope variants from early in infection have variable sensitivity to neutralization and to inhibitors of viral entry". AIDS 21 (6): 693–702. March 2007. doi:10.1097/qad.0b013e32805e8727. PMID 17413690. 
  12. ↑ "Coronavirus: Repurposing drugs to protect human cells" (in en-US). 2020-04-30. https://www.mercurynews.com/coronavirus-repurposing-drugs-to-protect-human-cells. 
  13. ↑ Zhang, Sarah (2020-03-23). "Why a Tiny Colorado County Can Offer COVID-19 Tests to Every Resident" (in en-US). https://www.theatlantic.com/science/archive/2020/03/coronavirus-tests-everyone-tiny-colorado-county/608590/. 
  14. ↑ Goldman, Author Bruce (2020-05-05). "How chloroquine, coronavirus duke it out inside a dish" (in en-US). https://scopeblog.stanford.edu/2020/05/05/how-chloroquine-coronavirus-duke-it-out-inside-an-infected-cell/. 
  15. ↑ Kaiser, Jocelyn (8 February 2017). "Chan Zuckerberg Biohub funds first crop of 47 investigators" (in en). https://www.science.org/content/article/chan-zuckerberg-biohub-funds-first-crop-47-investigators. 
  16. ↑ "A Push for Biomedical Innovation: Three Chan Zuckerberg Biohub Stories" (in en). Stanford University. https://medicine.stanford.edu/2019-report/zuckerberg-biohub-stories.html. 
  17. ↑ "NIH Announces 2013 High-Risk, High-Reward Research Awards" (in EN). 2015-08-05. https://www.nih.gov/news-events/news-releases/nih-announces-2013-high-risk-high-reward-research-awards. 

External links



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