Biology:(+)-epicubenol synthase
From HandWiki
Short description: Class of enzymes
| (+)-epicubenol synthase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 4.2.3.64 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
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(+)-Epicubenol synthase (EC 4.2.3.64, farnesyl pyrophosphate cyclase) is an enzyme with systematic name (2E,6E)-farnesyl-diphosphate diphosphate-lyase ((+)-epicubenol-forming).[1][2][3][4][5] This enzyme catalyses the following chemical reaction
- (2E,6E)-farnesyl diphosphate + H2O [math]\displaystyle{ \rightleftharpoons }[/math] (+)-epicubenol + diphosphate
This enzyme requires Mg2+.
References
- ↑ "Epicubenol synthase and the enzymatic cyclization of farnesyl diphosphate". J. Am. Chem. Soc. 115 (18): 8103–8106. 1993. doi:10.1021/ja00071a023.
- ↑ "Biosynthesis of (+)-epicubenol.". Tetrahedron Lett. 35 (30): 5355–5358. 1994. doi:10.1016/s0040-4039(00)73498-8.
- ↑ "Epicubenol synthase and the stereochemistry of the enzymatic cyclization of farnesyl and nerolidyl diphosphate". J. Am. Chem. Soc. 117 (20): 5602–5603. 1995. doi:10.1021/ja00125a029.
- ↑ "Bioynthesis of (+)-cubenene and (+)-epicubenol by cell-free extracts of cultured cells of Heteroscyphus planus and cyclization of [2H]farnesyl diphosphates". J. Chem. Soc., Perkin Trans. 1 (15): 1935–1939. 1995. doi:10.1039/p19950001935.
- ↑ "In vitro biosynthesis of cadinanes by cell-free extracts of cultured cells of Heteroscyphus planus". J. Chem. Soc., Perkin Trans. 1 (14): 2065–2070. 1997. doi:10.1039/a701145h.
External links
- (+)-epicubenol+synthase at the US National Library of Medicine Medical Subject Headings (MeSH)
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