Biology:(−)-endo-fenchol synthase

From HandWiki
Short description: Class of enzymes
(−)-endo-fenchol synthase
Identifiers
EC number4.2.3.10
CAS number117758-41-5
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO

The enzyme (−)-endo-Fenchol synthase (EC 4.2.3.10) catalyzes the chemical reaction

geranyl diphosphate + H2O [math]\displaystyle{ \rightleftharpoons }[/math] (−)-endo-fenchol + diphosphate

This enzyme belongs to the family of lyases, specifically those carbon-oxygen lyases acting on phosphates. The systematic name of this enzyme class is geranyl-diphosphate diphosphate-lyase [cyclizing, (−)-endo-fenchol-forming]. Other names in common use include (−)-endo-fenchol cyclase, and geranyl pyrophosphate:(−)-endo-fenchol cyclase. This enzyme participates in monoterpenoid biosynthesis.

References

  • "Monoterpene biosynthesis: mechanistic evaluation of the geranyl pyrophosphate:(−)-endo-fenchol cyclase from fennel (Foeniculum vulgare)". Arch. Biochem. Biophys. 269 (2): 507–16. 1989. doi:10.1016/0003-9861(89)90134-3. PMID 2919880. 
  • "Biosynthesis of monoterpenes. Stereochemistry of the enzymatic cyclization of geranyl pyrophosphate to (−)-endo-fenchol". J. Biol. Chem. 263 (30): 15449–53. 1988. doi:10.1016/S0021-9258(19)37609-4. PMID 3170591.