Biology:(RS)-1-benzyl-1,2,3,4-tetrahydroisoquinoline N-methyltransferase

From HandWiki
Short description: Class of enzymes
(RS)-1-benzyl-1,2,3,4-tetrahydroisoquinoline N-methyltransferase
Identifiers
EC number2.1.1.115
CAS number132084-82-3
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO

In enzymology, a (RS)-1-benzyl-1,2,3,4-tetrahydroisoquinoline N-methyltransferase is an enzyme that catalyzes the chemical reaction:[1]

EC 2.1.1.115 rxn.png
S-adenosyl-L-methionine + (RS)-1-benzyl-1,2,3,4-tetrahydroisoquinoline [math]\displaystyle{ \rightleftharpoons }[/math] S-adenosyl-L-homocysteine + N-methyl-(RS)-1-benzyl-1,2,3,4-tetrahydroisoquinoline

This enzyme participates in alkaloid biosynthesis.

Nomenclature

This enzyme belongs to the family of transferases, specifically those transferring one-carbon group methyltransferases. The systematic name of this enzyme class is S-adenosyl-L-methionine:(RS)-1-benzyl-1,2,3,4-tetrahydroisoquinoline N-methyltransferase. This enzyme is also called norreticuline N-methyltransferase.

References

  1. "Purification and characterization of three isoforms of S-adenosyl-L-methionine: (R,S)-tetrahydrobenzyl-isoquinoline N-methyltransferase from Berberis koetineana cell cultures". Phytochemistry 29 (11): 3491–3497. 1990. doi:10.1016/0031-9422(90)85263-F.