Biology:17-alpha-hydroxyprogesterone aldolase
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Short description: Class of enzymes
| 17α-Hydroxyprogesterone aldolase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 4.1.2.30 | ||||||||
| CAS number | 62213-24-5 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
In enzymology, a 17α-hydroxyprogesterone aldolase (EC 4.1.2.30) is an enzyme that catalyzes the chemical reaction
- 17α-hydroxyprogesterone [math]\displaystyle{ \rightleftharpoons }[/math] androst-4-en-3,17-dione + acetaldehyde
Hence, this enzyme has one substrate, 17α-hydroxyprogesterone, and two products, androst-4-en-3,17-dione and acetaldehyde.
This enzyme belongs to the family of lyases, specifically the aldehyde-lyases, which cleave carbon-carbon bonds. The systematic name of this enzyme class is 17α-hydroxyprogesterone acetaldehyde-lyase (4-androstene-3,17-dione-forming). Other names in common use include C-17/C-20-lyase, and 17α-hydroxyprogesterone acetaldehyde-lyase. This enzyme participates in androgen and estrogen metabolism.
References
- "Bioconversion of steroids in vitro by testes from autoimmunized rabbits". Hoppe-Seyler's Z. Physiol. Chem. 355 (6): 716–20. 1974. doi:10.1515/bchm2.1974.355.1.716. PMID 4435747.
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