Biology:2,4-diaminopentanoate dehydrogenase
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Short description: Class of enzymes
| 2,4-diaminopentanoate dehydrogenase | |||||||||
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| Identifiers | |||||||||
| EC number | 1.4.1.12 | ||||||||
| CAS number | 39346-26-4 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
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In enzymology, a 2,4-diaminopentanoate dehydrogenase (EC 1.4.1.12) is an enzyme that catalyzes the chemical reaction
- 2,4-diaminopentanoate + H2O + NAD(P)+ [math]\displaystyle{ \rightleftharpoons }[/math] 2-amino-4-oxopentanoate + NH3 + NAD(P)H + H+
The 4 substrates of this enzyme are 2,4-diaminopentanoate, H2O, NAD+, and NADP+, whereas its 5 products are 2-amino-4-oxopentanoate, NH3, NADH, NADPH, and H+.
This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-NH2 group of donors with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is 2,4-diaminopentanoate:NAD(P)+ oxidoreductase (deaminating). This enzyme is also called 2,4-diaminopentanoic acid C4 dehydrogenase. This enzyme participates in 3 metabolic pathways: lysine degradation, arginine and proline metabolism, and d-arginine and d-ornithine metabolism.
References
- "2,4-diaminopentanoic acid C 4 dehydrogenase. Purification and properties of the protein". J. Biol. Chem. 248 (2): 385–8. 1973. PMID 4684685.
- Stadtman TC (1973). "Lysine metabolism by clostridia. XIIB 2,4-Diaminohexanoate dehydrogenase (2,4-diaminopentanoate dehydrogenase)". Adv. Enzymol. Relat. Areas Mol. Biol. 38: 441–445.
- "Ornithine metabolism by Clostridium sticklandii. Oxidation of ornithine to 2-amino-4-ketopentanoic acid via 2,4-diaminopentanoic acid; participation of B12 coenzyme, pyridoxal phosphate, and pyridine nucleotide". J. Biol. Chem. 245 (22): 5914–26. 1970. PMID 4394942.
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