Biology:2-Amino-4-deoxychorismate dehydrogenase

From HandWiki
Short description: Class of enzymes
2-amino-4-deoxychorismate dehydrogenase
Identifiers
EC number1.3.99.24
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum

2-Amino-4-deoxychorismate dehydrogenase (EC 1.3.99.24, ADIC dehydrogenase, 2-amino-2-deoxyisochorismate dehydrogenase, SgcG) is an enzyme with systematic name (2S)-2-amino-4-deoxychorismate:FMN oxidoreductase.[1][2] This enzyme catalyses the following chemical reaction

(2S)-2-amino-4-deoxychorismate + FMN [math]\displaystyle{ \rightleftharpoons }[/math] 3-(1-carboxyvinyloxy)anthranilate + FMNH2

This enzyme participates in the formation of the benzoxazolinate moiety of the enediyne antitumour antibiotic C-1027].

References

  1. "Biosynthesis of the enediyne antitumor antibiotic C-1027 involves a new branching point in chorismate metabolism". Proceedings of the National Academy of Sciences of the United States of America 105 (2): 494–9. January 2008. doi:10.1073/pnas.0708750105. PMID 18182490. Bibcode2008PNAS..105..494V. 
  2. "The benzoxazolinate of C-1027 confers intercalative DNA binding". J. Am. Chem. Soc. 117 (34): 8877–8878. 1995. doi:10.1021/ja00139a032. 

External links