Biology:2-Coumarate reductase

From HandWiki
Short description: Class of enzymes
2-coumarate reductase
Identifiers
EC number1.3.1.11
CAS number37251-10-8
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO

In enzymology, a 2-coumarate reductase or melilotate dehydrogenase (EC 1.3.1.11) is an enzyme that catalyzes the chemical reaction

3-(2-hydroxyphenyl)propanoate + NAD+ [math]\displaystyle{ \rightleftharpoons }[/math] 2-coumarate + NADH + H+

Thus, the two substrates of this enzyme are 3-(2-hydroxyphenyl)propanoate and NAD+, whereas its 3 products are 2-coumarate, NADH, and H+.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-CH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is 3-(2-hydroxyphenyl)propanoate:NAD+ oxidoreductase. This enzyme participates in phenylalanine metabolism.

References

  • "The metabolism of coumarin by a microorganism. II. The reduction of o-coumaric acid to melilotic acid". Biochemistry 3 (12): 1944–7. December 1964. doi:10.1021/bi00900a027. PMID 14269315.