Biology:2-furoyl-CoA dehydrogenase
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Short description: Class of enzymes
| 2-furoyl-CoA dehydrogenase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 1.3.99.8 | ||||||||
| CAS number | 9068-18-2 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
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In enzymology, a 2-furoyl-CoA dehydrogenase (EC 1.3.99.8) is an enzyme that catalyzes the chemical reaction
- 2-furoyl-CoA + H2O + acceptor [math]\displaystyle{ \rightleftharpoons }[/math] S-(5-hydroxy-2-furoyl)-CoA + reduced acceptor
The 3 substrates of this enzyme are 2-furoyl-CoA, H2O, and acceptor, whereas its two products are S-(5-hydroxy-2-furoyl)-CoA and reduced acceptor.
This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-CH group of donor with other acceptors. The systematic name of this enzyme class is 2-furoyl-CoA:acceptor 5-oxidoreductase (hydroxylating). Other names in common use include furoyl-CoA hydroxylase, 2-furoyl coenzyme A hydroxylase, 2-furoyl coenzyme A dehydrogenase, and 2-furoyl-CoA:(acceptor) 5-oxidoreductase (hydroxylating). It employs one cofactor, copper.
References
- "Purification and properties of 2-furoyl-coenzyme A hydroxylase from Pseudomonas putida F2". Biochem. J. 130 (1): 121–32. 1972. PMID 4655411.
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