Biology:2-hydroxy-3-oxoadipate synthase

From HandWiki
Short description: Class of enzymes
2-hydroxy-3-oxoadipate synthase
Identifiers
EC number2.2.1.5
CAS number9054-72-2
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO

In enzymology, a 2-hydroxy-3-oxoadipate synthase (EC 2.2.1.5) is an enzyme that catalyzes the following chemical reaction:

2-oxoglutarate + glyoxylate [math]\displaystyle{ \rightleftharpoons }[/math] 2-hydroxy-3-oxoadipate + CO2

The two substrates of this enzyme are 2-oxoglutarate and glyoxylate, whereas its two products are 2-hydroxy-3-oxoadipate and CO2.

This enzyme belongs to the family of transferases, specifically those transferring aldehyde or ketonic groups (transaldolases and transketolases, respectively). Other names in common use include 2-hydroxy-3-oxoadipate glyoxylate-lyase (carboxylating), alpha-ketoglutaric-glyoxylic carboligase, and oxoglutarate: glyoxylate carboligase. This enzyme participates in glyoxylate and dicarboxylate metabolism. It employs one cofactor, thiamin diphosphate.

References

  • "Carboligase activity of alpha-ketoglutarate dehydrogenase". Biochemistry 9 (5): 1148–53. 1970. doi:10.1021/bi00807a015. PMID 5418712. 
  • "Isolation and identification of 5-hydroxy-4-ketovaleric acid as a product of alpha-ketoglutarate: glyoxylate carboligase". Biochemistry 7 (1): 333–7. 1968. doi:10.1021/bi00841a042. PMID 4320439. 
  • "The synergistic decarboxylation of glyoxalate and 2-oxoglutarate by an enzyme system from pig-liver mitochondria". Biochem. J. 102: 885–897. 1967.