Biology:2-hydroxyisoflavanone dehydratase
| 2-hydroxyisoflavanone dehydratase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 4.2.1.105 | ||||||||
| CAS number | 56022-25-4 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
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The enzyme 2-hydroxyisoflavanone dehydratase (EC 4.2.1.105) catalyzes the chemical reaction
- REDIRECT Template:Chemical reaction
This enzyme belongs to the family of lyases, specifically the hydro-lyases, which cleave carbon-oxygen bonds. The systematic name of this enzyme class is 2,7,4′-trihydroxyisoflavanone hydro-lyase (daidzein-forming). This enzyme is also called 2,7,4′-trihydroxyisoflavanone hydro-lyase.[1] This enzyme forms part of the pathway to isoflavones from flavonoids.[2][3] The starting material, 2,4',7-trihydroxyisoflavanone, is produced from liquiritigenin by the enzyme isoflavonoid synthase[4]
- REDIRECT Template:Chemical reaction
2-hydroxyisoflavanone dehydratase also acts on the intermediate tetrahydroxyisoflavanone produced from naringenin, leading to genistein.[5]
- REDIRECT Template:Chemical reaction
The variant GmHID1 from Glycine max shows both these activities.[5].
References
- ↑ Enzyme 4.2.1.105 at KEGG Pathway Database.
- ↑ "Purification of 2-hydroxyisoflavanone dehydratase from the cell cultures of Pueraria lobata". Phytochemistry 49 (2): 497–505. 1998. doi:10.1016/S0031-9422(98)00266-0.
- ↑ Ververidis Filippos, F; Trantas Emmanouil; Douglas Carl; Vollmer Guenter; Kretzschmar Georg; Panopoulos Nickolas (October 2007). "Biotechnology of flavonoids and other phenylpropanoid-derived natural products. Part I: Chemical diversity, impacts on plant biology and human health". Biotechnology Journal 2 (10): 1214–34. doi:10.1002/biot.200700084. PMID 17935117.
- ↑ "Key amino acid residues required for aryl migration catalysed by the cytochrome P450 2-hydroxyisoflavanone synthase". The Plant Journal 31 (5): 555–64. September 2002. doi:10.1046/j.1365-313x.2002.01378.x. PMID 12207646.
- ↑ 5.0 5.1 Bauters, Lander; Lander Bauers; Stojilković, Boris; Gheysen, Godelieve (2021-08-19). "Pathogens pulling the strings: Effectors manipulating salicylic acid and phenylpropanoid biosynthesis in plants". Molecular Plant Pathology (British Society for Plant Pathology (Wiley)) 22 (11): 1436–1448. doi:10.1111/mpp.13123. ISSN 1464-6722. PMID 34414650. Bibcode: 2021MolPP..22.1436B.
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