Biology:2-hydroxymuconate tautomerase
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Short description: Class of enzymes
| 2-hydroxymuconate tautomerase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 5.3.2.6 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
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2-hydroxymuconate tautomerase (EC 5.3.2.6, 4-oxalocrotonate tautomerase, 4-oxalocrotonate isomerase, cnbG (gene), praC (gene), xylH (gene)) is an enzyme with systematic name (2Z,4E)-2-hydroxyhexa-2,4-dienedioate keto-enol isomerase.[1][2][3][4][5][6] This enzyme catalyses the following chemical reaction
- (2Z,4E)-2-hydroxyhexa-2,4-dienedioate [math]\displaystyle{ \rightleftharpoons }[/math] (3E)-2-oxohex-3-enedioate
Involved in the meta-cleavage pathway for the degradation of phenols, modified phenols and catechols.
References
- ↑ "Chemical and enzymatic ketonization of 2-hydroxymuconate, a conjugated enol". J. Am. Chem. Soc. 113 (8): 3154–3162. 1991. doi:10.1021/ja00008a052.
- ↑ "Stereospecific ketonization of 2-hydroxymuconate by 4-oxalocrotonate tautomerase and 5-(carboxymethyl)-2-hydroxymuconate isomerase". J. Am. Chem. Soc. 114 (26): 10104–10110. 1992. doi:10.1021/ja00052a002.
- ↑ "Enzymatic ketonization of 2-hydroxymuconate: specificity and mechanism investigated by the crystal structures of two isomerases". Biochemistry 35 (3): 792–802. January 1996. doi:10.1021/bi951732k. PMID 8547259.
- ↑ "Catalytic role of the amino-terminal proline in 4-oxalocrotonate tautomerase: affinity labeling and heteronuclear NMR studies". Biochemistry 35 (3): 803–13. January 1996. doi:10.1021/bi951077g. PMID 8547260.
- ↑ "Kinetic and stereochemical analysis of YwhB, a 4-oxalocrotonate tautomerase homologue in Bacillus subtilis: mechanistic implications for the YwhB- and 4-oxalocrotonate tautomerase-catalyzed reactions". Biochemistry 46 (42): 11919–29. October 2007. doi:10.1021/bi701231a. PMID 17902707.
- ↑ "Uncovering the protocatechuate 2,3-cleavage pathway genes". Journal of Bacteriology 191 (21): 6758–68. November 2009. doi:10.1128/JB.00840-09. PMID 19717587.
External links
- 2-hydroxymuconate+tautomerase at the US National Library of Medicine Medical Subject Headings (MeSH)
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