Biology:2-methylcitrate dehydratase
From HandWiki
Short description: Class of enzymes
| 2-methylcitrate dehydratase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 4.2.1.79 | ||||||||
| CAS number | 80891-26-5 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
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The enzyme 2-methylcitrate dehydratase (EC 4.2.1.79) catalyzes the chemical reaction
- (2S,3S)-2-hydroxybutane-1,2,3-tricarboxylate [math]\displaystyle{ \rightleftharpoons }[/math] (Z)-but-2-ene-1,2,3-tricarboxylate + H2O
This enzyme belongs to the family of lyases, specifically the hydro-lyases, which cleave carbon-oxygen bonds. The systematic name of this enzyme class is (2S,3S)-2-hydroxybutane-1,2,3-tricarboxylate hydro-lyase [(Z)-but-2-ene-1,2,3-tricarboxylate-forming]. Other names in common use include 2-methylcitrate hydro-lyase, PrpD, and 2-hydroxybutane-1,2,3-tricarboxylate hydro-lyase. This enzyme participates in propanoate metabolism.
Structural studies
As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code 1SZQ.
References
- "Purification and properties of 2-methylcitrate dehydratase from Yarrowia lipolytica". Agric. Biol. Chem. 45 (12): 2831–2837. 1981. doi:10.1271/bbb1961.45.2831.
- "Oxidation of propionate to pyruvate in Escherichia coli. Involvement of methylcitrate dehydratase and aconitase". Eur. J. Biochem. 269 (24): 6184–94. 2002. doi:10.1046/j.1432-1033.2002.03336.x. PMID 12473114.
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