Biology:3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA hydratase
From HandWiki
Short description: Enzyme
| 3α,7α,12α-trihydroxy-5β-cholest-24-enoyl-CoA hydratase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 4.2.1.107 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
The enzyme 3α,7α,12α-trihydroxy-5β-cholest-24-enoyl-CoA hydratase (EC 4.2.1.107) catalyzes the chemical reaction
- (24R,25R)-3α,7α,12α,24-tetrahydroxy-5β-cholestanoyl-CoA [math]\displaystyle{ \rightleftharpoons }[/math]
- (24E)-3α,7α,12α-trihydroxy-5β-cholest-24-enoyl-CoA + H2O
Nomenclature
This enzyme belongs to the family of lyases, specifically the hydro-lyases, which cleave carbon-oxygen bonds. The systematic name of this enzyme class is (24R,25R)-3α,7α,12α,24-tetrahydroxy-5beta-cholestanoyl-CoA hydro-lyase [(24E)-3α,7α,12α-trihydroxy-5β-cholest-24-enoyl-CoA-forming]. Other names in common use include 46 kDa hydratase 2, and (24R,25R)-3α,7α,12α,24-tetrahydroxy-5β-cholestanoyl-CoA hydro-lyase.
References
Further reading
- "Recombinant 2-enoyl-CoA hydratase derived from rat peroxisomal multifunctional enzyme 2: role of the hydratase reaction in bile acid synthesis". The Biochemical Journal 328 (2): 377–82. December 1997. doi:10.1042/bj3280377. PMID 9371691.
- "The reactions catalyzed by the inducible bifunctional enzyme of rat liver peroxisomes cannot lead to the formation of bile acids". Biochemical and Biophysical Research Communications 221 (2): 271–8. April 1996. doi:10.1006/bbrc.1996.0585. PMID 8619845.
- Kokawa NI; Morisaki M (1988). "Synthesis and determination of stereochemistry of four diastereoisomers at the C-24 and C-25 positions of 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestan-26-oic acid and cholic acid". Chem. Pharm. Bull. 36: 134–141. doi:10.1248/cpb.36.134.
- Sonoda Y; Sato Y; Morisaki M (1988). "Non-stereoselective conversion of the four diastereoisomers at the C-24 and C-25 positions of 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestan-26-oic acid and cholic acid". Chem. Pharm. Bull. 36: 142–145. doi:10.1248/cpb.36.142.
- "Conjugation reactions catalyzed by bifunctional proteins related to beta-oxidation in bile acid biosynthesis". Steroids 66 (2): 107–14. February 2001. doi:10.1016/S0039-128X(00)00217-8. PMID 11146090.
- "The enzymes, regulation, and genetics of bile acid synthesis". Annual Review of Biochemistry 72: 137–74. 2003. doi:10.1146/annurev.biochem.72.121801.161712. PMID 12543708.
 |  |
