Biology:4-hydroxybenzoate polyprenyltransferase
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Short description: Class of enzymes
4-hydroxybenzoate polyprenyltransferase | |||||||||
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Identifiers | |||||||||
EC number | 2.5.1.39 | ||||||||
CAS number | 9030-77-7 | ||||||||
Databases | |||||||||
IntEnz | IntEnz view | ||||||||
BRENDA | BRENDA entry | ||||||||
ExPASy | NiceZyme view | ||||||||
KEGG | KEGG entry | ||||||||
MetaCyc | metabolic pathway | ||||||||
PRIAM | profile | ||||||||
PDB structures | RCSB PDB PDBe PDBsum | ||||||||
Gene Ontology | AmiGO / QuickGO | ||||||||
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In enzymology, a 4-hydroxybenzoate polyprenyltransferase (EC 2.5.1.39) is an enzyme that catalyzes the chemical reaction
- a polyprenyl diphosphate + 4-hydroxybenzoate [math]\displaystyle{ \rightleftharpoons }[/math] diphosphate + a 4-hydroxy-3-polyprenylbenzoate
Thus, the two substrates of this enzyme are a polyprenyl diphosphate and 4-hydroxybenzoate, whereas its two products are diphosphate and 4-hydroxy-3-polyprenylbenzoate.
This enzyme belongs to the family of transferases, specifically those transferring aryl or alkyl groups other than methyl groups. This enzyme participates in ubiquinone biosynthesis.[1]
Nomenclature
The systematic name of this enzyme class is polyprenyl-diphosphate:4-hydroxybenzoate polyprenyltransferase. Other names in common use include:
- nonaprenyl-4-hydroxybenzoate transferase,
- 4-hydroxybenzoate transferase,
- p-hydroxybenzoate dimethylallyltransferase,
- p-hydroxybenzoate polyprenyltransferase,
- p-hydroxybenzoic acid-polyprenyl transferase,
- p-hydroxybenzoic-polyprenyl transferase, and
- 4-hydroxybenzoate nonaprenyltransferase
References
- ↑ "Characterization of polyprenyldiphosphate: 4-hydroxybenzoate polyprenyltransferase from Escherichia coli". Biochim Biophys Acta 1212 (1): 93–102. 1994-04-14. doi:10.1016/0005-2760(94)90193-7. PMID 8155731.
- "Nonaprenyl-4-hydroxybenzoate transferase, an enzyme involved in ubiquinone biosynthesis, in the endoplasmic reticulum-Golgi system of rat liver". J. Biol. Chem. 265 (2): 1158–64. 1990. PMID 2295606.
![]() | Original source: https://en.wikipedia.org/wiki/4-hydroxybenzoate polyprenyltransferase.
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