Biology:4-oxalmesaconate hydratase

From HandWiki
Short description: Class of enzymes
4-oxalmesaconate hydratase
Identifiers
EC number4.2.1.83
CAS number85204-95-1
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO

The enzyme 4-oxalmesaconate hydratase (EC 4.2.1.83) catalyzes the chemical reaction

2-hydroxy-4-oxobutane-1,2,4-tricarboxylate [math]\displaystyle{ \rightleftharpoons }[/math] (1E,3E)-4-hydroxybuta-1,3-diene-1,2,4-tricarboxylate + H2O

This enzyme belongs to the family of lyases, specifically the hydro-lyases, which cleave carbon-oxygen bonds. The systematic name of this enzyme class is (1E,3E)-4-hydroxybuta-1,3-diene-1,2,4-tricarboxylate 1,2-hydro-lyase (2-hydroxy-4-oxobutane-1,2,4-tricarboxylate-forming). Other names in common use include 4-carboxy-2-oxohexenedioate hydratase, 4-carboxy-2-oxobutane-1,2,4-tricarboxylate 2,3-hydro-lyase, oxalmesaconate hydratase, γ-oxalmesaconate hydratase, 4-carboxy-2-oxohexenedioate hydratase, and 2-hydroxy-4-oxobutane-1,2,4-tricarboxylate 2,3-hydro-lyase. This enzyme participates in benzoate degradation via hydroxylation.

References

  • "Purification and properties of 2-pyrone-4,6-dicarboxylate hydrolase". Journal of Biochemistry 93 (2): 557–65. February 1983. PMID 6841353.