Biology:ABCG1
From HandWiki
Short description: Mammalian protein found in Homo sapiens
 Generic protein structure example |
ATP-binding cassette sub-family G member 1 is a protein that in humans is encoded by the ABCG1 gene.[1][2][3] It is a homolog of the well-known Drosophila gene white.
Function
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the White subfamily (subfamily G). It is involved in macrophage cholesterol and phospholipids transport, and may regulate cellular lipid homeostasis in other cell types. Several alternative splice variants have been identified.[3]
See also
References
- ↑ "Cloning of the cDNA for a human homologue of the Drosophila white gene and mapping to chromosome 21q22.3". American Journal of Human Genetics 59 (1): 66–75. Jul 1996. PMID 8659545.
- ↑ "Expression and functional characterization of ABCG1 splice variant ABCG1(666)". FEBS Letters 580 (18): 4551–9. Aug 2006. doi:10.1016/j.febslet.2006.07.006. PMID 16870176. Bibcode: 2006FEBSL.580.4551E.
- ↑ 3.0 3.1 "Entrez Gene: ABCG1 ATP-binding cassette, sub-family G (WHITE), member 1". https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=9619.
Further reading
- "Role of ABCG1 and other ABCG family members in lipid metabolism". Journal of Lipid Research 42 (10): 1513–20. Oct 2001. doi:10.1016/S0022-2275(20)32205-7. PMID 11590207.
- "A "double adaptor" method for improved shotgun library construction". Analytical Biochemistry 236 (1): 107–13. Apr 1996. doi:10.1006/abio.1996.0138. PMID 8619474.
- "Molecular cloning of a mammalian ABC transporter homologous to Drosophila white gene". Mammalian Genome 7 (9): 673–6. Sep 1996. doi:10.1007/s003359900203. PMID 8703120.
- "Isolation and characterization of a mammalian homolog of the Drosophila white gene". Gene 185 (1): 77–85. Jan 1997. doi:10.1016/S0378-1119(96)00633-6. PMID 9034316.
- "Large-scale concatenation cDNA sequencing". Genome Research 7 (4): 353–8. Apr 1997. doi:10.1101/gr.7.4.353. PMID 9110174.
- "ABCG1 (ABC8), the human homolog of the Drosophila white gene, is a regulator of macrophage cholesterol and phospholipid transport". Proceedings of the National Academy of Sciences of the United States of America 97 (2): 817–22. Jan 2000. doi:10.1073/pnas.97.2.817. PMID 10639163. Bibcode: 2000PNAS...97..817K.
- "Human white/murine ABC8 mRNA levels are highly induced in lipid-loaded macrophages. A transcriptional role for specific oxysterols". The Journal of Biological Chemistry 275 (19): 14700–7. May 2000. doi:10.1074/jbc.275.19.14700. PMID 10799558.
- "Refined localization of autosomal recessive nonsyndromic deafness DFNB10 locus using 34 novel microsatellite markers, genomic structure, and exclusion of six known genes in the region". Genomics 68 (1): 22–9. Aug 2000. doi:10.1006/geno.2000.6253. PMID 10950923.
- "Genomic organization and characterization of the promoter of the human ATP-binding cassette transporter-G1 (ABCG1) gene". Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression 1494 (1–2): 175–80. Nov 2000. doi:10.1016/s0167-4781(00)00215-3. PMID 11072082.
- "Genomic sequence and structure of the human ABCG1 (ABC8) gene". Biochemical and Biophysical Research Communications 280 (1): 121–31. Jan 2001. doi:10.1006/bbrc.2000.4089. PMID 11162488. Bibcode: 2001BBRC..280..121L.
- "The zinc finger protein 202 (ZNF202) is a transcriptional repressor of ATP binding cassette transporter A1 (ABCA1) and ABCG1 gene expression and a modulator of cellular lipid efflux". The Journal of Biological Chemistry 276 (15): 12427–33. Apr 2001. doi:10.1074/jbc.M100218200. PMID 11279031.
- "Expression of the ATP-binding cassette transporter gene ABCG1 (ABC8) in Tangier disease". Biochemical and Biophysical Research Communications 283 (4): 821–30. May 2001. doi:10.1006/bbrc.2001.4863. PMID 11350058. Bibcode: 2001BBRC..283..821L.
- "Characterization of the human ABCG1 gene: liver X receptor activates an internal promoter that produces a novel transcript encoding an alternative form of the protein". The Journal of Biological Chemistry 276 (42): 39438–47. Oct 2001. doi:10.1074/jbc.M105863200. PMID 11500512.
- "Bacterial lipopolysaccharide induces expression of ABCA1 but not ABCG1 via an LXR-independent pathway". Journal of Lipid Research 43 (6): 952–9. Jun 2002. doi:10.1016/S0022-2275(20)30470-3. PMID 12032171.
- "Functional expression and characterization of the human ABCG1 and ABCG4 proteins: indications for heterodimerization". Biochemical and Biophysical Research Communications 320 (3): 860–7. Jul 2004. doi:10.1016/j.bbrc.2004.06.037. PMID 15240127. Bibcode: 2004BBRC..320..860C.
External links
- ABCG1+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
- Human ABCG1 genome location and ABCG1 gene details page in the UCSC Genome Browser.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
 |  |
