Biology:Acetate CoA-transferase
| acetate CoA-transferase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 2.8.3.8 | ||||||||
| CAS number | 37278-35-6 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
In enzymology, an acetate CoA-transferase (EC 2.8.3.8) is an enzyme that catalyzes the chemical reaction
- acyl-CoA + acetate [math]\displaystyle{ \rightleftharpoons }[/math] a fatty acid anion + acetyl-CoA
Thus, the two substrates of this enzyme are acyl-CoA and acetate, whereas its two products are long-chain carboxylate anion and acetyl-CoA.
This enzyme belongs to the family of transferases, specifically the CoA-transferases. The systematic name of this enzyme class is acyl-CoA:acetate CoA-transferase. Other names in common use include acetate coenzyme A-transferase, butyryl CoA:acetate CoA transferase, butyryl coenzyme A transferase, and succinyl-CoA:acetate CoA transferase.
This enzyme participates in 4 metabolic pathways:
- benzoate metabolism via ligation of CoA
- propanoate metabolism
- butanoate metabolism
- two-component system.
Structural studies
As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code 1K6D.
References
- "Growth of Escherichia coli on fatty acids: requirement for coenzyme A transferase activity". Biochem. Biophys. Res. Commun. 33 (6): 902–8. 1968. doi:10.1016/0006-291X(68)90397-5. PMID 4884054.
- "Degradation of aromatics and chloroaromatics by Pseudomonas sp strain B13: purification and characterization of 3-oxoadipate:succinyl-coenzyme A (CoA) transferase and 3-oxoadipyl-CoA thiolase". J. Bacteriol. 184 (1): 207–15. 2002. doi:10.1128/JB.184.1.207-215.2002. PMID 11741862.
- "Degradation of aromatics and chloroaromatics by Pseudomonas sp strain B13: cloning, characterization, and analysis of sequences encoding 3-oxoadipate:succinyl-coenzyme A (CoA) transferase and 3-oxoadipyl-CoA thiolase". J. Bacteriol. 184 (1): 216–23. 2002. doi:10.1128/JB.184.1.216-223.2002. PMID 11741863.
External links
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