Biology:Arogenate dehydrogenase
| cyclohexadienyl dehydrogenase | |||||||||
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| Identifiers | |||||||||
| EC number | 1.3.1.43 | ||||||||
| CAS number | 64295-75-6 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
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In enzymology, an arogenate dehydrogenase (EC 1.3.1.43) is an enzyme that catalyzes the chemical reaction
- L-arogenate + NAD+ [math]\displaystyle{ \rightleftharpoons }[/math] L-tyrosine + NADH + CO2
Thus, the two substrates of this enzyme are L-arogenate and NAD+, whereas its 3 products are L-tyrosine, NADH, and CO2.
This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-CH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is L-arogenate:NAD+ oxidoreductase (decarboxylating). Other names in common use include arogenic dehydrogenase (ambiguous), cyclohexadienyl dehydrogenase, pretyrosine dehydrogenase (ambiguous), and L-arogenate:NAD+ oxidoreductase. This enzyme participates in phenylalanine, tyrosine and tryptophan biosynthesis and novobiocin biosynthesis.
Structural studies
As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code 2F1K.
References
- "Blue-green bacteria synthesise L-tyrosine by the pretyrosine pathway". Nature 247 (439): 290–2. 1974. doi:10.1038/247290a0. PMID 4206476. Bibcode: 1974Natur.247..290S.
- "Enzymology of L-tyrosine biosynthesis in corn (Zea mays)". Phytochemistry 20 (6): 1289–1292. 1981. doi:10.1016/0031-9422(81)80023-4.
- "Purification of arogenate dehydrogenase from Phenylobacterium immobile". FEBS Lett. 179 (2): 208–12. 1985. doi:10.1016/0014-5793(85)80519-6. PMID 3967752.
- "Arogenate dehydrogenase from Phenylobacterium immobile". Methods Enzymol.. Methods in Enzymology 142: 513–518. 1987. doi:10.1016/S0076-6879(87)42064-8. ISBN 978-0-12-182042-8.
- "Structure of D-prephenyllactate. A carboxycyclohexadienyl metabolite from Neurospora crassa". J. Biol. Chem. 263 (33): 17284–90. 1988. PMID 2972718.
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