Biology:Arogenate dehydrogenase (NAD(P)+)
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Short description: Class of enzymes
| Arogenate dehydrogenase (NAD(P)+) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 1.3.1.79 | ||||||||
| CAS number | 64295-75-6 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
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In enzymology, an arogenate dehydrogenase [NAD(P)+] (EC 1.3.1.79) is an enzyme that catalyzes the chemical reaction
- L-arogenate + NAD(P)+ [math]\displaystyle{ \rightleftharpoons }[/math] L-tyrosine + NAD(P)H + CO2
The 3 substrates of this enzyme are L-arogenate, NAD+, and NADP+, whereas its 4 products are L-tyrosine, NADH, NADPH, and CO2.
This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-CH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is L-arogenate:NAD(P)+ oxidoreductase (decarboxylating). Other names in common use include arogenic dehydrogenase (ambiguous), cyclohexadienyl dehydrogenase, and pretyrosine dehydrogenase (ambiguous).
References
- "Tyrosine biosynthesis in Sorghum bicolor: isolation and regulatory properties of arogenate dehydrogenase". Z. Naturforsch. C 41 (1–2): 69–78. 1986. PMID 2939643.
- "Arogenate dehydrogenase". Methods Enzymol.. Methods in Enzymology 142: 488–94. 1987. doi:10.1016/S0076-6879(87)42060-0. ISBN 978-0-12-182042-8. PMID 3600376.
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