Biology:Biotin—(methylmalonyl-CoA-carboxytransferase) ligase
From HandWiki
| Biotin—[methylmalonyl-CoA-carboxytransferase] ligase | |||||||||
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| Identifiers | |||||||||
| EC number | 6.3.4.9 | ||||||||
| CAS number | 37318-66-4 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
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In enzymology, a biotin—[methylmalonyl-CoA-carboxytransferase] ligase (EC 6.3.4.9) is an enzyme that catalyzes the chemical reaction
- ATP + biotin + apo-[methylmalonyl-CoA:pyruvate carboxytransferase] [math]\displaystyle{ \rightleftharpoons }[/math] AMP + diphosphate + [methylmalonyl-CoA:pyruvate carboxytransferase]
The 3 substrates of this enzyme are ATP, biotin, and apo-[methylmalonyl-CoA:pyruvate carboxytransferase], whereas its 3 products are AMP, diphosphate, and methylmalonyl-CoA:pyruvate carboxytransferase.
This enzyme belongs to the family of ligases, specifically those forming generic carbon-nitrogen bonds. The systematic name of this enzyme class is biotin:apo[methylmalonyl-CoA:pyruvate carboxytransferase] ligase (AMP-forming). This enzyme participates in biotin metabolism.
References
- "The enzymatic synthesis of holotranscarboxylase from apotranscarboxylase and (+)-biotin. I. Purification of the apoenzyme and synthetase; characteristics of the reaction". J. Biol. Chem. 239: 2858–2864. 1964.
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