Biology:Biotin-dependent malonate decarboxylase

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Biotin-dependent malonate decarboxylase
Identifiers
EC number4.1.1.89
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum

Biotin-dependent malonate decarboxylase (EC 4.1.1.89, malonate decarboxylase (with biotin), malonate decarboxylase) is an enzyme with systematic name malonate carboxy-lyase (biotin-dependent).[1][2][3][4][5][6][7] This enzyme catalyses the following chemical reaction

malonate + H+ [math]\displaystyle{ \rightleftharpoons }[/math] acetate + CO2

Two types of malonate decarboxylase are currently known, both of which form multienzyme complexes.

References

  1. "Malonate decarboxylase of Malonomonas rubra, a novel type of biotin-containing acetyl enzyme". European Journal of Biochemistry 207 (1): 117–23. July 1992. doi:10.1111/j.1432-1033.1992.tb17028.x. PMID 1628643. http://nbn-resolving.de/urn:nbn:de:bsz:352-opus-62564. 
  2. "Purification and characterization of a cytoplasmic enzyme component of the Na+-activated malonate decarboxylase system of Malonomonas rubra: acetyl-S-acyl carrier protein: malonate acyl carrier protein-SH transferase". Archives of Microbiology 162 (1–2): 48–56. 1994. doi:10.1007/bf00264372. PMID 18251085. 
  3. "The acyl carrier protein of malonate decarboxylase of Malonomonas rubra contains 2'-(5"-phosphoribosyl)-3'-dephosphocoenzyme A as a prosthetic group". Biochemistry 35 (15): 4689–96. April 1996. doi:10.1021/bi952873p. PMID 8664258. 
  4. "Sequence of a gene cluster from Malonomonas rubra encoding components of the malonate decarboxylase Na+ pump and evidence for their function". European Journal of Biochemistry 245 (1): 103–15. April 1997. doi:10.1111/j.1432-1033.1997.00103.x. PMID 9128730. 
  5. "Stereochemical course of malonate decarboxylase in Malonomonas rubra has biotin decarboxylation with retention". J. Am. Chem. Soc. 117 (3): 1153–1154. 1995. doi:10.1021/ja00108a042. 
  6. "Malonate metabolism: biochemistry, molecular biology, physiology, and industrial application". Journal of Biochemistry and Molecular Biology 35 (5): 443–51. September 2002. doi:10.5483/bmbrep.2002.35.5.443. PMID 12359084. 
  7. "Enzymic and genetic basis for bacterial growth on malonate". Molecular Microbiology 25 (1): 3–10. July 1997. doi:10.1046/j.1365-2958.1997.4611824.x. PMID 11902724. 

External links