Biology:Cholate—CoA ligase

From HandWiki
Cholate—CoA ligase
Identifiers
EC number6.2.1.7
CAS number9027-90-1
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum

Cholate—CoA ligase (EC 6.2.1.7, BAL, bile acid CoA ligase, bile acid coenzyme A ligase, choloyl-CoA synthetase, choloyl coenzyme A synthetase, cholic thiokinase, cholate thiokinase, cholic acid:CoA ligase, 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoyl coenzyme A synthetase, 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoate-CoA ligase, 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoate-CoA synthetase, THCA-CoA ligase, 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanate—CoA ligase, 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanate:CoA ligase (AMP-forming), cholyl-CoA synthetase, trihydroxycoprostanoyl-CoA synthetase) is an enzyme with systematic name cholate:CoA ligase (AMP-forming).[1][2][3][4][5][6][7] This enzyme catalyses the following chemical reaction

(1) ATP + cholate + CoA [math]\displaystyle{ \rightleftharpoons }[/math] AMP + diphosphate + choloyl-CoA
(2) ATP + (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oate + CoA [math]\displaystyle{ \rightleftharpoons }[/math] AMP + diphosphate + (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoyl-CoA

This enzyme requires Mg2+ for activity.

References

  1. "The enzymic activation of cholic acid by guinea-pig-liver microsomes". The Biochemical Journal 62 (3): 427–33. March 1956. PMID 13303991. 
  2. "The breakdown of adenosine triphosphate accompanying cholic acid activation by guinea-pig liver microsomes". The Biochemical Journal 65 (2): 315–21. February 1957. PMID 13403911. 
  3. "Subcellular localization of 3 alpha, 7 alpha-dihydroxy- and 3 alpha,7 alpha,12 alpha-trihydroxy-5 beta-cholestanoyl-coenzyme A ligase(s) in rat liver". Journal of Lipid Research 29 (8): 997–1004. August 1988. PMID 3183523. 
  4. "Subcellular distribution and characteristics of trihydroxycoprostanoyl-CoA synthetase in rat liver". The Biochemical Journal 257 (1): 221–9. January 1989. PMID 2521999. 
  5. "The bile acid-inducible baiB gene from Eubacterium sp. strain VPI 12708 encodes a bile acid-coenzyme A ligase". Journal of Bacteriology 174 (7): 2065–71. April 1992. PMID 1551828. 
  6. "Purification and characterization of a rat liver bile acid coenzyme A ligase from rat liver microsomes". Archives of Biochemistry and Biophysics 348 (1): 15–24. December 1997. doi:10.1006/abbi.1997.0391. PMID 9390170. 
  7. "Molecular cloning and expression of rat liver bile acid CoA ligase". Journal of Lipid Research 43 (12): 2062–71. December 2002. doi:10.1194/jlr.M200260-JLR200. PMID 12454267. 

External links