Biology:Cholate—CoA ligase
| Cholate—CoA ligase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 6.2.1.7 | ||||||||
| CAS number | 9027-90-1 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
Cholate—CoA ligase (EC 6.2.1.7, BAL, bile acid CoA ligase, bile acid coenzyme A ligase, choloyl-CoA synthetase, choloyl coenzyme A synthetase, cholic thiokinase, cholate thiokinase, cholic acid:CoA ligase, 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoyl coenzyme A synthetase, 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoate-CoA ligase, 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoate-CoA synthetase, THCA-CoA ligase, 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanate—CoA ligase, 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanate:CoA ligase (AMP-forming), cholyl-CoA synthetase, trihydroxycoprostanoyl-CoA synthetase) is an enzyme with systematic name cholate:CoA ligase (AMP-forming).[1][2][3][4][5][6][7] This enzyme catalyses the following chemical reaction
- (1) ATP + cholate + CoA [math]\displaystyle{ \rightleftharpoons }[/math] AMP + diphosphate + choloyl-CoA
- (2) ATP + (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oate + CoA [math]\displaystyle{ \rightleftharpoons }[/math] AMP + diphosphate + (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoyl-CoA
This enzyme requires Mg2+ for activity.
References
- ↑ "The enzymic activation of cholic acid by guinea-pig-liver microsomes". The Biochemical Journal 62 (3): 427–33. March 1956. PMID 13303991.
- ↑ "The breakdown of adenosine triphosphate accompanying cholic acid activation by guinea-pig liver microsomes". The Biochemical Journal 65 (2): 315–21. February 1957. PMID 13403911.
- ↑ "Subcellular localization of 3 alpha, 7 alpha-dihydroxy- and 3 alpha,7 alpha,12 alpha-trihydroxy-5 beta-cholestanoyl-coenzyme A ligase(s) in rat liver". Journal of Lipid Research 29 (8): 997–1004. August 1988. PMID 3183523.
- ↑ "Subcellular distribution and characteristics of trihydroxycoprostanoyl-CoA synthetase in rat liver". The Biochemical Journal 257 (1): 221–9. January 1989. PMID 2521999.
- ↑ "The bile acid-inducible baiB gene from Eubacterium sp. strain VPI 12708 encodes a bile acid-coenzyme A ligase". Journal of Bacteriology 174 (7): 2065–71. April 1992. PMID 1551828.
- ↑ "Purification and characterization of a rat liver bile acid coenzyme A ligase from rat liver microsomes". Archives of Biochemistry and Biophysics 348 (1): 15–24. December 1997. doi:10.1006/abbi.1997.0391. PMID 9390170.
- ↑ "Molecular cloning and expression of rat liver bile acid CoA ligase". Journal of Lipid Research 43 (12): 2062–71. December 2002. doi:10.1194/jlr.M200260-JLR200. PMID 12454267.
External links
- Cholate---CoA+ligase at the US National Library of Medicine Medical Subject Headings (MeSH)
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