Biology:Cis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase
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Short description: Class of enzymes
| cis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 1.3.1.56 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
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In enzymology, a cis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase (EC 1.3.1.56) is an enzyme that catalyzes the chemical reaction
- cis-3-phenylcyclohexa-3,5-diene-1,2-diol + NAD+ [math]\displaystyle{ \rightleftharpoons }[/math] biphenyl-2,3-diol + NADH + H+
Thus, the two substrates of this enzyme are cis-3-phenylcyclohexa-3,5-diene-1,2-diol and NAD+, whereas its 3 products are biphenyl-2,3-diol, NADH, and H+.
This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-CH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is cis-3-phenylcyclohexa-3,5-diene-1,2-diol:NAD+ oxidoreductase. This enzyme is also called 2,3-dihydro-2,3-dihydroxybiphenyl dehydrogenase. This enzyme participates in biphenyl degradation.
References
- "Characterization of active recombinant 2,3-dihydro-2,3-dihydroxybiphenyl dehydrogenase from Comamonas testosteroni B-356 and sequence of the encoding gene (bphB)". Appl. Environ. Microbiol. 62 (8): 2710–5. 1996. PMID 8702262.
- "Identification of the bphA and bphB genes of Pseudomonas sp. strains KKS102 involved in degradation of biphenyl and polychlorinated biphenyls". Biochem. Biophys. Res. Commun. 202 (2): 850–6. 1994. doi:10.1006/bbrc.1994.2008. PMID 8048958.
- "Genetic analysis of a Pseudomonas locus encoding a pathway for biphenyl/polychlorinated biphenyl degradation". Gene 130 (1): 47–55. 1993. doi:10.1016/0378-1119(93)90345-4. PMID 8344527.
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