Biology:Corydaline synthase
From HandWiki
Short description: Enzyme
| Corydaline synthase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 2.1.1.147 | ||||||||
| CAS number | 155807-67-3 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
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Corydaline synthase (EC 2.1.1.147) is an enzyme that catalyzes the chemical reaction
- REDIRECT Template:Chemical reaction
This is a methylation reaction in which palmatine is converted to its corydaline. The methyl group comes from the cofactor, S-adenosyl methionine (SAM), which becomes S-adenosyl-L-homocysteine (SAH). The reaction also requires nicotinamide adenine dinucleotide phosphate (NADPH). The enzyme was characterised from Corydalis cava.[1]
This enzyme belongs to the family of transferases, specifically those transferring one-carbon group methyltransferases. The systematic name of this enzyme class is S-adenosyl-L-methionine:protoberberine 13-C-methyltransferase.[2]
References
- ↑ "The formation of corydaline and related alkaloids in Corydalis cava in vivo and in vitro". Can. J. Chem. 72 (1): 170–175. 1994. doi:10.1139/v94-026. Bibcode: 1994CaJCh..72..170R.
- ↑ Enzyme 2.1.1.147 at KEGG Pathway Database.
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