Biology:Cyclic pyranopterin monophosphate synthase
From HandWiki
| Cyclic pyranopterin monophosphate synthase | |||||||||
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| Identifiers | |||||||||
| EC number | 4.1.99.18 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
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Cyclic pyranopterin monophosphate synthase (EC 4.1.99.18, MOCS1A, MoaA, MoaC, molybdenum cofactor biosynthesis protein 1) is an enzyme with systematic name GTP 8,9-lyase (cyclic pyranopterin monophosphate-forming).[1][2][3][4][5][6][7] This enzyme catalyses the following chemical reaction
- GTP [math]\displaystyle{ \rightleftharpoons }[/math] cyclic pyranopterin monophosphate + diphosphate
This enzyme catalyses an early step in the biosynthesis of molybdopterin.
References
- ↑ "Rearrangement reactions in the biosynthesis of molybdopterin--an NMR study with multiply 13C/15N labelled precursors". European Journal of Biochemistry 255 (1): 24–36. July 1998. doi:10.1046/j.1432-1327.1998.2550024.x. PMID 9692897.
- ↑ "Investigation of the early steps of molybdopterin biosynthesis in Escherichia coli through the use of in vivo labeling studies". The Journal of Biological Chemistry 270 (3): 1082–7. January 1995. doi:10.1074/jbc.270.3.1082. PMID 7836363.
- ↑ "Characterization of MOCS1A, an oxygen-sensitive iron-sulfur protein involved in human molybdenum cofactor biosynthesis". The Journal of Biological Chemistry 279 (33): 34721–32. August 2004. doi:10.1074/jbc.M313398200. PMID 15180982.
- ↑ "Crystal structure of the S-adenosylmethionine-dependent enzyme MoaA and its implications for molybdenum cofactor deficiency in humans". Proceedings of the National Academy of Sciences of the United States of America 101 (35): 12870–5. August 2004. doi:10.1073/pnas.0404624101. PMID 15317939.
- ↑ "The crystal structure of Escherichia coli MoaB suggests a probable role in molybdenum cofactor synthesis". The Journal of Biological Chemistry 279 (40): 42139–46. October 2004. doi:10.1074/jbc.M407694200. PMID 15269205.
- ↑ "Binding of 5'-GTP to the C-terminal FeS cluster of the radical S-adenosylmethionine enzyme MoaA provides insights into its mechanism". Proceedings of the National Academy of Sciences of the United States of America 103 (18): 6829–34. May 2006. doi:10.1073/pnas.0510711103. PMID 16632608.
- ↑ "ENDOR spectroscopy shows that guanine N1 binds to [4Fe-4S cluster II of the S-adenosylmethionine-dependent enzyme MoaA: mechanistic implications"]. Journal of the American Chemical Society 131 (26): 9184–5. July 2009. doi:10.1021/ja903978u. PMID 19566093.
External links
- Cyclic+pyranopterin+monophosphate+synthase at the US National Library of Medicine Medical Subject Headings (MeSH)
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