Biology:DAK (gene)
From HandWiki
 Generic protein structure example |
Triokinase/FMN cyclase is an enzyme that in humans is encoded by the DAK gene.[1]
Function
This gene is a member of the family of dihydroxyacetone kinases, which have a protein structure distinct from other kinases. The product of this gene phosphorylates dihydroxyacetone, and also catalyzes the formation of riboflavin 4',5'-phosphate (aka cyclic FMN) from FAD. Several alternatively spliced transcript variants have been identified, but the full-length nature of only one has been determined.[1]
References
Further reading
- "Negative regulation of MDA5- but not RIG-I-mediated innate antiviral signaling by the dihydroxyacetone kinase". Proceedings of the National Academy of Sciences of the United States of America 104 (28): 11706–11. July 2007. doi:10.1073/pnas.0700544104. PMID 17600090.
- "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Research 16 (1): 55–65. January 2006. doi:10.1101/gr.4039406. PMID 16344560.
- "Identification of human and rat FAD-AMP lyase (cyclic FMN forming) as ATP-dependent dihydroxyacetone kinases". Biochemical and Biophysical Research Communications 338 (4): 1682–9. December 2005. doi:10.1016/j.bbrc.2005.10.142. PMID 16289032.
- "A comprehensive update of the sequence and structure classification of kinases". BMC Structural Biology 5: 6. 2006. doi:10.1186/1472-6807-5-6. PMID 15771780.
- "Purification, characterization, and substrate and inhibitor structure-activity studies of rat liver FAD-AMP lyase (cyclizing): preference for FAD and specificity for splitting ribonucleoside diphosphate-X into ribonucleotide and a five-atom cyclic phosphodiester of X, either a monocyclic compound or a cis-bicyclic phosphodiester-pyranose fusion". Biochemistry 40 (45): 13710–22. November 2001. doi:10.1021/bi0157159. PMID 11695920.
- "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene 200 (1–2): 149–56. October 1997. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
- "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene 138 (1–2): 171–4. January 1994. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
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