Biology:Delta14-sterol reductase
From HandWiki
Short description: Class of enzymes
| delta14-sterol reductase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 1.3.1.70 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
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In enzymology, a Delta14-sterol reductase (EC 1.3.1.70) is an enzyme that catalyzes the chemical reaction
- 4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol + NADP+ [math]\displaystyle{ \rightleftharpoons }[/math] 4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol + NADPH + H+
Thus, the two substrates of this enzyme are 4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol and NADP+, whereas its 3 products are 4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol, NADPH, and H+.
This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-CH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is 4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol:NADP+ Delta14-oxidoreductase. This enzyme participates in biosynthesis of steroids.
References
- "Delta14-sterol reductase in Saccharomyces cerevisiae". Biochim. Biophys. Acta 531 (3): 301–7. 1978. doi:10.1016/0005-2760(78)90212-6. PMID 32908.
- "Microsomal enzymes of cholesterol biosynthesis from lanosterol Characterization, solubilization, and partial purification of NADPH-dependent delta 8,14-steroid 14-reductase". J. Biol. Chem. 259 (21): 13413–23. 1984. PMID 6444198.
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