Biology:Desmoglein
From HandWiki
Short description: Family of proteins
| Desmoglein | |
|---|---|
| Identifiers | |
| Symbol | DSG |
| InterPro | IPR009123 |
| Membranome | 243 |
The desmogleins are a family of desmosomal cadherins consisting of proteins DSG1, DSG2, DSG3, and DSG4. They play a role in the formation of desmosomes that join cells to one another.[1]
Pathology
Desmogleins are targeted in the autoimmune disease pemphigus.[2][3][4]
Desmoglein proteins are a type of cadherin, which is a transmembrane protein that binds with other cadherins to form junctions known as desmosomes between cells. These desmoglein proteins thus hold cells together, but, when the body starts producing antibodies against desmoglein, these junctions break down, and this results in subsequent blister or vesicle formation.[5][6]
References
- ↑ Kline, Crystal F.; Mohler, Peter J. (2013-01-01), Bennett, Vann, ed., "Chapter Four - Evolving Form to Fit Function: Cardiomyocyte Intercalated Disc and Transverse-Tubule Membranes" (in en), Current Topics in Membranes, Functional Organization of Vertebrate Plasma Membrane (Academic Press) 72: 121–158, doi:10.1016/b978-0-12-417027-8.00004-0, PMID 24210429, http://www.sciencedirect.com/science/article/pii/B9780124170278000040, retrieved 2020-10-23
- ↑ "Pemphigus foliaceus IgG causes dissociation of desmoglein 1–containing junctions without blocking desmoglein 1 transinteraction". J. Clin. Invest. 115 (11): 3157–65. November 2005. doi:10.1172/JCI23475. PMID 16211092.
- ↑ "Desmoglein 4 in hair follicle differentiation and epidermal adhesion: evidence from inherited hypotrichosis and acquired pemphigus vulgaris". Cell 113 (2): 249–60. April 2003. doi:10.1016/S0092-8674(03)00273-3. PMID 12705872.
- ↑ "Autoantibodies against desmocollins in European patients with pemphigus". Clin. Exp. Dermatol. 34 (8): 898–903. May 2009. doi:10.1111/j.1365-2230.2009.03241.x. PMID 19456767. https://zenodo.org/record/3436428.[yes|permanent dead link|dead link}}]
- ↑ A Clinician's Guide to Pemphigus Vulgarishttp://www.springer.com/gp/book/9783319677583
- ↑ Bolognia JL, Jorizzo JL, Schaffer JV, editors. Dermatology. 3rd ed. Philadelphia: Elsevier Saunders; 2012
External links
- Histology image: 20502loa – Histology Learning System at Boston University
- Desmogleins at the US National Library of Medicine Medical Subject Headings (MeSH)
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