Biology:Diferric-transferrin reductase
| diferric-transferrin reductase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 1.16.1.2 | ||||||||
| CAS number | 105238-49-1 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
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In enzymology, a diferric-transferrin reductase (EC 1.16.1.2) is an enzyme that catalyzes the chemical reaction
- transferrin[Fe(II)]2 + NAD+ + H+ [math]\displaystyle{ \rightleftharpoons }[/math] transferrin[Fe(III)]2 + NADH
The 3 substrates of this enzyme are transferrin[Fe(II)]2, NAD+, and H+, whereas its two products are transferrin[Fe(III)]2 and NADH.
This enzyme belongs to the family of oxidoreductases, specifically those oxidizing metal ion with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is transferrin[Fe(II)]2:NAD+ oxidoreductase. Other names in common use include diferric transferrin reductase, NADH diferric transferrin reductase, and transferrin reductase. This enzyme participates in porphyrin and chlorophyll metabolism.
Structural studies
As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code 1L5T.
References
- "Transplasmalemma electron transport from cells is part of a diferric transferrin reductase system". Biochem. Biophys. Res. Commun. 139 (3): 1117–23. 1986. doi:10.1016/S0006-291X(86)80293-5. PMID 3767994.
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