Biology:Dihydroorotate dehydrogenase (fumarate)
From HandWiki
| Dihydroorotate dehydrogenase (fumarate) | |||||||||
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| Identifiers | |||||||||
| EC number | 1.3.98.1 | ||||||||
| CAS number | 2603876 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
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Dihydroorotate dehydrogenase (fumarate) (EC 1.3.98.1, dihydroorotate oxidase, pyr4 (gene)) is an enzyme with systematic name (S)-dihydroorotate:fumarate oxidoreductase.[1][2][3][4][5][6] This enzyme catalyses the following chemical reaction
- (S)-dihydroorotate + fumarate [math]\displaystyle{ \rightleftharpoons }[/math] orotate + succinate
This enzyme contains FMN.
References
- ↑ "Active site of dihydroorotate dehydrogenase A from Lactococcus lactis investigated by chemical modification and mutagenesis". Biochemistry 36 (51): 16197–205. December 1997. doi:10.1021/bi971628y. PMID 9405053.
- ↑ "The crystal structure of Lactococcus lactis dihydroorotate dehydrogenase A complexed with the enzyme reaction product throws light on its enzymatic function". Protein Science 7 (6): 1269–79. June 1998. doi:10.1002/pro.5560070601. PMID 9655329.
- ↑ "Lactococcus lactis dihydroorotate dehydrogenase A mutants reveal important facets of the enzymatic function". The Journal of Biological Chemistry 278 (31): 28812–22. August 2003. doi:10.1074/jbc.M303767200. PMID 12732650.
- ↑ "Dihydroorotate dehydrogenase from Saccharomyces cerevisiae: spectroscopic investigations with the recombinant enzyme throw light on catalytic properties and metabolism of fumarate analogues". FEMS Yeast Research 7 (6): 897–904. September 2007. doi:10.1111/j.1567-1364.2007.00275.x. PMID 17617217.
- ↑ "Structures of Trypanosoma cruzi dihydroorotate dehydrogenase complexed with substrates and products: atomic resolution insights into mechanisms of dihydroorotate oxidation and fumarate reduction". Biochemistry 47 (41): 10881–91. October 2008. doi:10.1021/bi800413r. PMID 18808149.
- ↑ "Kinetic mechanism and catalysis of Trypanosoma cruzi dihydroorotate dehydrogenase enzyme evaluated by isothermal titration calorimetry". Analytical Biochemistry 399 (1): 13–22. April 2010. doi:10.1016/j.ab.2009.11.018. PMID 19932077.
External links
- Dihydroorotate+dehydrogenase+(fumarate) at the US National Library of Medicine Medical Subject Headings (MeSH)
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