Biology:Ectoine synthase
From HandWiki
| Ectoine synthase | |||||||||
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| Identifiers | |||||||||
| EC number | 4.2.1.108 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
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The enzyme ectoine synthase (EC [1]) catalyzes the chemical reaction
- (2S)-4-acetamido-2-aminobutanoate [math]\displaystyle{ \rightleftharpoons }[/math] L-ectoine + H2O
This enzyme belongs to the family of lyases, specifically the hydro-lyases, which cleave carbon-oxygen bonds. The systematic name of this enzyme class is (2S)-4-acetamido-2-aminobutanoate (L-ectoine-forming). Other names in common use include N-acetyldiaminobutyrate dehydratase, N-acetyldiaminobutanoate dehydratase, L-ectoine synthase, EctC, and 4-N-acetyl-L-2,4-diaminobutanoate hydro-lyase (L-ectoine-forming). This enzyme participates in glycine, serine and threonine metabolism.
References
- "The biosynthesis of ectoine". FEMS Microbiol. Lett. 71 (1–2): 157–162. 1990. doi:10.1111/j.1574-6968.1990.tb03815.x.
- "Characterization of biosynthetic enzymes for ectoine as a compatible solute in a moderately halophilic eubacterium, Halomonas elongata". J. Bacteriol. 181 (1): 91–9. 1999. PMID 9864317.
- "Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp". Appl. Environ. Microbiol. 68 (2): 772–83. 2002. doi:10.1128/AEM.68.2.772-783.2002. PMID 11823218.
- "Characterization of genes for the biosynthesis of the compatible solute ectoine from Marinococcus halophilus and osmoregulated expression in Escherichia coli". Microbiology 143 (4): 1141–9. 1997. doi:10.1099/00221287-143-4-1141. PMID 9141677.
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