Biology:Galactonolactone dehydrogenase
From HandWiki
| L-galactonolactone dehydrogenase | |||||||||
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| Identifiers | |||||||||
| EC number | 1.3.2.3 | ||||||||
| CAS number | 2603847 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
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L-galactonolactone dehydrogenase (EC 1.3.2.3, galactonolactone dehydrogenase, L-galactono-gamma-lactone dehydrogenase, L-galactono-gamma-lactone:ferricytochrome-c oxidoreductase, GLDHase, GLDase) is an enzyme with systematic name L-galactono-1,4-lactone:ferricytochrome-c oxidoreductase.[1][2][3][4][5] This enzyme catalyses the following chemical reaction
- (1) L-galactono-1,4-lactone + 2 ferricytochrome c [math]\displaystyle{ \rightleftharpoons }[/math] L-ascorbate + 2 ferrocytochrome c + 2 H+
- (2) L-ascorbate + 2 ferricytochrome c [math]\displaystyle{ \rightleftharpoons }[/math] L-dehydroascorbate + 2 ferrocytochrome c + 2 H+ (spontaneous)
This enzyme catalyses the final step in the biosynthesis of L-ascorbic acid in plants and other photosynthetic eukaryotes.[6]
References
- ↑ Mapson, L.W.; Breslow, E. (1957). "Properties of partially purified L-galactono-γ-lactone dehydrogenase". Biochem. J. 65: 29.
- ↑ "Biological synthesis of L-ascorbic acid: the conversion of L-galactono-gamma-lactone into L-ascorbic acid by plant mitochondria". The Biochemical Journal 56 (1): 21–8. January 1954. doi:10.1042/bj0560021. PMID 13126087.
- ↑ "Synthesis of L-ascorbic acid in plants and animals". The Biochemical Journal 56 (1): 1–15. January 1954. doi:10.1042/bj0560001. PMID 13126085.
- ↑ "Purification and properties of L-galactono-gamma-lactone dehydrogenase, a key enzyme for ascorbic acid biosynthesis, from sweet potato roots". Journal of Biochemistry 117 (1): 120–4. January 1995. doi:10.1093/oxfordjournals.jbchem.a124697. PMID 7775377.
- ↑ "Isolation of a cDNA coding for L-galactono-gamma-lactone dehydrogenase, an enzyme involved in the biosynthesis of ascorbic acid in plants. Purification, characterization, cDNA cloning, and expression in yeast". The Journal of Biological Chemistry 272 (48): 30009–16. November 1997. doi:10.1074/jbc.272.48.30009. PMID 9374475.
- ↑ "Evolution of alternative biosynthetic pathways for vitamin C following plastid acquisition in photosynthetic eukaryotes". eLife 4. March 2015. doi:10.7554/eLife.06369. PMID 25768426.
External links
- L-galactonolactone+dehydrogenase at the US National Library of Medicine Medical Subject Headings (MeSH)
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