Biology:Galactosylceramide sulfotransferase

From HandWiki
Short description: Class of enzymes
galactosylceramide sulfotransferase
Identifiers
EC number2.8.2.11
CAS number9081-06-5
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO

In enzymology, a galactosylceramide sulfotransferase (EC 2.8.2.11) is an enzyme that catalyzes the chemical reaction

3'-phosphoadenylyl sulfate + a galactosylceramide [math]\displaystyle{ \rightleftharpoons }[/math] adenosine 3',5'-bisphosphate + a galactosylceramidesulfate

Thus, its two substrates are 3'-phosphoadenylyl sulfate and galactosylceramide, and its two products are adenosine 3',5'-bisphosphate and galactosylceramidesulfate.

It belongs to the family of transferases, specifically the sulfotransferases, which transfer sulfur-containing groups. The systematic name of this enzyme class is 3'-phosphoadenylyl-sulfate:galactosylceramide 3'-sulfotransferase. Other names in common use include GSase, 3'-phosphoadenosine-5'-phosphosulfate-cerebroside sulfotransferase, galactocerebroside sulfotransferase, galactolipid sulfotransferase, glycolipid sulfotransferase, and glycosphingolipid sulfotransferase. This enzyme participates in sphingolipid metabolism.

References

  • "Metabolism of sulfatides. I. The effect of galactocerebrosides on the synthesis of sulfatides". Biochem. Biophys. Res. Commun. 20 (2): 109–13. 1965. doi:10.1016/0006-291X(65)90331-1. PMID 5850675. 
  • "Association of elevated sulfatides and sulfotransferase activities with human renal cell carcinoma". Cancer Res. 49 (2): 335–9. 1989. PMID 2562926.