Biology:Gamma-glutamyl hydrolase

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Short description: Protein-coding gene in the species Homo sapiens

Ghk.

Gamma-glutamyl hydrolase
Identifiers
EC number3.4.19.9
CAS number9074-87-7
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
A representation of the 3D structure of the protein myoglobin showing turquoise α-helices.
Generic protein structure example


Gamma-glutamyl hydrolase is an enzyme[1][2][3][4] that catalyses the following chemical reaction:

Hydrolysis of a gamma-glutamyl bond

This lysosomal or secreted, thiol-dependent peptidase, most active at acidic pH.

In humans, gamma-glutamyl hydrolase is encoded by the GGH gene.[3][5][6] This gene catalyzes the hydrolysis of folylpoly-gamma-glutamates and antifolylpoly-gamma-glutamates by the removal of gamma-linked polyglutamates and glutamate.[6]

Nomenclature

Gamma-glutamyl hydrolase is also known as conjugase, folate conjugase, lysosomal gamma-glutamyl carboxypeptidase, gamma-Glu-X carboxypeptidase, pteroyl-poly-gamma-glutamate hydrolase, carboxypeptidase G, folic acid conjugase, poly(gamma-glutamic acid) endohydrolase, polyglutamate hydrolase, poly(glutamic acid) hydrolase II, pteroylpoly-gamma-glutamyl hydrolase.

Interactive pathway map

References

  1. "The properties of the secreted gamma-glutamyl hydrolases from H35 hepatoma cells". Biochim. Biophys. Acta 1164 (3): 227–35. August 1993. doi:10.1016/0167-4838(93)90253-n. PMID 8343522. 
  2. "Effects of gamma-glutamyl hydrolase on folyl and antifolylpolyglutamates in cultured H35 hepatoma cells". Mol. Pharmacol. 48 (3): 505–11. September 1995. PMID 7565632. 
  3. 3.0 3.1 "Human gamma-glutamyl hydrolase: cloning and characterization of the enzyme expressed in vitro". Proc. Natl. Acad. Sci. U.S.A. 93 (19): 10134–8. September 1996. doi:10.1073/pnas.93.19.10134. PMID 8816764. Bibcode1996PNAS...9310134Y. 
  4. "Identification, cloning, and sequencing of a cDNA coding for rat gamma-glutamyl hydrolase". J. Biol. Chem. 271 (15): 8525–8. April 1996. doi:10.1074/jbc.271.15.8525. PMID 8621474. 
  5. "Structural organization of the human gamma-glutamyl hydrolase gene". Gene 238 (2): 463–70. Dec 1999. doi:10.1016/S0378-1119(99)00362-5. PMID 10570974. 
  6. 6.0 6.1 "Entrez Gene: GGH gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase)". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8836. 

Further reading

External links