Biology:Gamma-glutamylhistamine synthase
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Short description: Class of enzymes
| γ-Glutamylhistamine synthase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 6.3.2.18 | ||||||||
| CAS number | 82904-08-3 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
In enzymology, a γ-glutamylhistamine synthase (EC 6.3.2.18) is an enzyme that catalyzes the chemical reaction
- ATP + L-glutamate + histamine [math]\displaystyle{ \rightleftharpoons }[/math] products of ATP breakdown + Nα-γ-L-glutamylhistamine
The 3 substrates of this enzyme are ATP, L-glutamate, and histamine, whereas its two products are products of ATP breakdown and Nalpha-gamma-L-glutamylhistamine.
This enzyme belongs to the family of ligases, specifically those forming carbon-nitrogen bonds as acid-D-amino-acid ligases (peptide synthases). The systematic name of this enzyme class is L-glutamate:histamine ligase. Other names in common use include gamma-glutaminylhistamine synthetase, and gamma-GHA synthetase.
References
- "An in vitro characterization of gamma-glutamylhistamine synthetase: a novel enzyme catalyzing histamine metabolism in the central nervous system of the marine mollusk, Aplysia californica". J. Neurochem. 38 (1): 204–14. 1982. doi:10.1111/j.1471-4159.1982.tb10873.x. PMID 6125565.
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